Involvement of the Intrarenal Renin-Angiotensin System in Experimental Models of Glomerulonephritis
Joint Authors
Kondo, Shuji
Kagami, Shoji
Urushihara, Maki
Kinoshita, Yukiko
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The intrarenal renin-angiotensin system (RAS) has several pathophysiologic functions not only in blood pressure regulation but also in the development of glomerulonephritis (GN).
Angiotensin II (Ang II) is the biologically active product of the RAS.
Locally produced Ang II induces inflammation, renal cell growth, mitogenesis, apoptosis, migration, and differentiation, regulates the gene expression of bioactive substances, and activates multiple intracellular signaling pathways, leading to tissue damage.
Activation of the Ang II type 1 (AT1) receptor pathway results in the production of proinflammatory mediators, cell proliferation, and extracellular matrix synthesis, which facilitates glomerular injury.
Previous studies have shown that angiotensin-converting enzyme inhibitors and/or AT1 receptor blockers have beneficial effects in experimental GN models and humans with various types of GN, and that these effects are more significant than their suppressive effects on blood pressure.
In this paper, we focus on intrarenal RAS activation in the pathophysiology of experimental models of GN.
American Psychological Association (APA)
Urushihara, Maki& Kinoshita, Yukiko& Kondo, Shuji& Kagami, Shoji. 2012. Involvement of the Intrarenal Renin-Angiotensin System in Experimental Models of Glomerulonephritis. BioMed Research International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-991798
Modern Language Association (MLA)
Urushihara, Maki…[et al.]. Involvement of the Intrarenal Renin-Angiotensin System in Experimental Models of Glomerulonephritis. BioMed Research International No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-991798
American Medical Association (AMA)
Urushihara, Maki& Kinoshita, Yukiko& Kondo, Shuji& Kagami, Shoji. Involvement of the Intrarenal Renin-Angiotensin System in Experimental Models of Glomerulonephritis. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-991798
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991798