Strategies for Enhancing Vaccine-Induced CTL Antitumor Immune Responses
Joint Authors
Lü, Mu-Han
Guo, Hong
Hu, Chang-Jiang
Luo, Gang
He, Bin
Yang, Shi-Ming
Xiao, Yü-Feng
Yong, Xin
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Vaccine-induced cytotoxic T lymphocytes (CTLs) play a critical role in adaptive immunity against cancers.
An important goal of current vaccine research is to induce durable and long-lasting functional CTLs that can mediate cytotoxic effects on tumor cells.
To attain this goal, there are four distinct steps that must be achieved.
To initiate a vaccine-induced CTL antitumor immune response, dendritic cells (DCs) must capture antigens derived from exogenous tumor vaccines in vivo or autologous DCs directly loaded in vitro with tumor antigens must be injected.
Next, tumor-antigen-loaded DCs must activate CTLs in lymphoid organs.
Subsequently, activated CTLs must enter the tumor microenvironment to perform their functions, at which point a variety of negative regulatory signals suppress the immune response.
Finally, CTL-mediated cytotoxic effects must overcome the tolerance induced by tumor cells.
Each step is a complex process that may be impeded in many ways.
However, if these steps happen under appropriate regulation, the vaccine-induced CTL antitumor immune response will be more successful.
For this reason, we should gain a better understanding of the basic mechanisms that govern the immune response.
This paper, based on the steps necessary to induce an immune response, discusses current strategies for enhancing vaccine-induced CTL antitumor immune responses.
American Psychological Association (APA)
Yong, Xin& Xiao, Yü-Feng& Luo, Gang& He, Bin& Lü, Mu-Han& Hu, Chang-Jiang…[et al.]. 2012. Strategies for Enhancing Vaccine-Induced CTL Antitumor Immune Responses. BioMed Research International،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-991800
Modern Language Association (MLA)
Yong, Xin…[et al.]. Strategies for Enhancing Vaccine-Induced CTL Antitumor Immune Responses. BioMed Research International No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-991800
American Medical Association (AMA)
Yong, Xin& Xiao, Yü-Feng& Luo, Gang& He, Bin& Lü, Mu-Han& Hu, Chang-Jiang…[et al.]. Strategies for Enhancing Vaccine-Induced CTL Antitumor Immune Responses. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-991800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991800