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Role of Vitamin D in Insulin Resistance
Joint Authors
Liao, Min-Tser
Wu, Chia-Chao
Lu, Kuo-Cheng
Sung, Chih-Chien
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Vitamin D is characterized as a regulator of homeostasis of bone and mineral metabolism, but it can also provide nonskeletal actions because vitamin D receptors have been found in various tissues including the brain, prostate, breast, colon, pancreas, and immune cells.
Bone metabolism, modulation of the immune response, and regulation of cell proliferation and differentiation are all biological functions of vitamin D.
Vitamin D may play an important role in modifying the risk of cardiometabolic outcomes, including diabetes mellitus (DM), hypertension, and cardiovascular disease.
The incidence of type 2 DM is increasing worldwide and results from a lack of insulin or inadequate insulin secretion following increases in insulin resistance.
Therefore, it has been proposed that vitamin D deficiency plays an important role in insulin resistance resulting in diabetes.
The potential role of vitamin D deficiency in insulin resistance has been proposed to be associated with inherited gene polymorphisms including vitamin D-binding protein, vitamin D receptor, and vitamin D 1alpha-hydroxylase gene.
Other roles have been proposed to involve immunoregulatory function by activating innate and adaptive immunity and cytokine release, activating inflammation by upregulation of nuclear factor κB and inducing tumor necrosis factor α, and other molecular actions to maintain glucose homeostasis and mediate insulin sensitivity by a low calcium status, obesity, or by elevating serum levels of parathyroid hormone.
These effects of vitamin D deficiency, either acting in concert or alone, all serve to increase insulin resistance.
Although there is evidence to support a relationship between vitamin D status and insulin resistance, the underlying mechanism requires further exploration.
The purpose of this paper was to review the current information available concerning the role of vitamin D in insulin resistance.
American Psychological Association (APA)
Sung, Chih-Chien& Liao, Min-Tser& Lu, Kuo-Cheng& Wu, Chia-Chao. 2012. Role of Vitamin D in Insulin Resistance. BioMed Research International،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-991818
Modern Language Association (MLA)
Sung, Chih-Chien…[et al.]. Role of Vitamin D in Insulin Resistance. BioMed Research International No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-991818
American Medical Association (AMA)
Sung, Chih-Chien& Liao, Min-Tser& Lu, Kuo-Cheng& Wu, Chia-Chao. Role of Vitamin D in Insulin Resistance. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-991818
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991818