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Antiproliferative and Anti-Invasive Effect of Piceatannol, a Polyphenol Present in Grapes and Wine, against Hepatoma AH109A Cells
Joint Authors
Miura, Yutaka
Yagasaki, Kazumi
Kita, Yuichiro
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Piceatannol is a stilbenoid, a metabolite of resveratrol found in red wine.
Piceatannol and sera from rats orally given piceatannol were found to dose-dependently suppress both the proliferation and invasion of AH109A hepatoma cells in culture.
Its antiproliferative effect was based on cell cycle arrest at lower concentration (25~50 μM) and on apoptosis induction at higher concentration (100 μM).
Piceatannol suppressed reactive oxygen species-potentiated invasive capacity by scavenging the intracellular reactive oxygen species.
These results suggest that piceatannol, unlike resveratrol, has a potential to suppress the hepatoma proliferation by inducing cell cycle arrest and apoptosis induction.
They also suggest that the antioxidative property of piceatannol, like resveratrol, may be involved in its anti-invasive action.
Subsequently, piceatannol was found to suppress the growth of solid tumor and metastasis in hepatoma-bearing rats.
Thus, piceatannol may be a useful anticancer natural product.
American Psychological Association (APA)
Kita, Yuichiro& Miura, Yutaka& Yagasaki, Kazumi. 2012. Antiproliferative and Anti-Invasive Effect of Piceatannol, a Polyphenol Present in Grapes and Wine, against Hepatoma AH109A Cells. BioMed Research International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991832
Modern Language Association (MLA)
Kita, Yuichiro…[et al.]. Antiproliferative and Anti-Invasive Effect of Piceatannol, a Polyphenol Present in Grapes and Wine, against Hepatoma AH109A Cells. BioMed Research International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-991832
American Medical Association (AMA)
Kita, Yuichiro& Miura, Yutaka& Yagasaki, Kazumi. Antiproliferative and Anti-Invasive Effect of Piceatannol, a Polyphenol Present in Grapes and Wine, against Hepatoma AH109A Cells. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991832
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991832