Alterations in Cell Cycle and Induction of Apoptotic Cell Death in Breast Cancer Cells Treated with α-Mangostin Extracted from Mangosteen Pericarp
Joint Authors
Iinuma, Munekazu
Otsuki, Yoshinori
Shibata, Masa-Aki
Kurose, Hitomi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The development of molecularly targeted drugs has greatly advanced cancer therapy, despite these drugs being associated with some serious problems.
Recently, increasing attention has been paid to the anticancer effects of natural products.
α-Mangostin, a xanthone isolated from the pericarp of mangosteen fruit, has been shown to induce apoptosis in various cancer cell lines and to exhibit antitumor activity in a mouse mammary cancer model.
In this study, we investigated the influence of α-mangostin on apoptosis and cell cycle in the human breast cancer cell line MDA-MB231 (carrying a p53 mutation, and HER2, ER, and PgR negative) in order to elucidate its anticancer mechanisms.
In α-mangostin-treated cells, induction of mitochondria-mediated apoptosis was observed.
On cell-cycle analysis, G1-phase arrest, increased p21cip1 expression and decreases in cyclins, cdc(s), CDKs and PCNA were observed.
In conclusion, α-mangostin may be useful as a therapeutic agent for breast cancer carrying a p53 mutation and having HER2- and hormone receptor-negative subtypes.
American Psychological Association (APA)
Kurose, Hitomi& Shibata, Masa-Aki& Iinuma, Munekazu& Otsuki, Yoshinori. 2012. Alterations in Cell Cycle and Induction of Apoptotic Cell Death in Breast Cancer Cells Treated with α-Mangostin Extracted from Mangosteen Pericarp. BioMed Research International،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-991833
Modern Language Association (MLA)
Kurose, Hitomi…[et al.]. Alterations in Cell Cycle and Induction of Apoptotic Cell Death in Breast Cancer Cells Treated with α-Mangostin Extracted from Mangosteen Pericarp. BioMed Research International No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-991833
American Medical Association (AMA)
Kurose, Hitomi& Shibata, Masa-Aki& Iinuma, Munekazu& Otsuki, Yoshinori. Alterations in Cell Cycle and Induction of Apoptotic Cell Death in Breast Cancer Cells Treated with α-Mangostin Extracted from Mangosteen Pericarp. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-991833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991833