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Insulin Resistance in Patients with Chronic Kidney Disease
Joint Authors
Lo, Lan
Liao, Min-Tser
Hung, Kuo-Chin
Wu, Chia-Chao
Lu, Kuo-Cheng
Sung, Chih-Chien
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Metabolic syndrome and its components are associated with chronic kidney disease (CKD) development.
Insulin resistance (IR) plays a central role in the metabolic syndrome and is associated with increased risk for CKD in nondiabetic patients.
IR is common in patients with mild-to-moderate stage CKD, even when the glomerular filtration rate is within the normal range.
IR, along with oxidative stress and inflammation, also promotes kidney disease.
In patients with end stage renal disease, IR is an independent predictor of cardiovascular disease and is linked to protein energy wasting and malnutrition.
Systemic inflammation, oxidative stress, elevated serum adipokines and fetuin-A, metabolic acidosis, vitamin D deficiency, depressed serum erythropoietin, endoplasmic reticulum stress, and suppressors of cytokine signaling all cause IR by suppressing insulin receptor-PI3K-Akt pathways in CKD.
In addition to adequate renal replacement therapy and correction of uremia-associated factors, thiazolidinedione, ghrelin, protein restriction, and keto-acid supplementation are therapeutic options.
Weight control, reduced daily prednisolone dosage, and the use of cyclosporin decrease the risk of developing new-onset diabetes after kidney transplantation.
Improved understanding of the pathogenic mechanisms underlying IR in CKD may lead to more effective therapeutic strategies to reduce uremia-associated morbidity and mortality.
American Psychological Association (APA)
Liao, Min-Tser& Sung, Chih-Chien& Hung, Kuo-Chin& Wu, Chia-Chao& Lo, Lan& Lu, Kuo-Cheng. 2012. Insulin Resistance in Patients with Chronic Kidney Disease. BioMed Research International،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-991841
Modern Language Association (MLA)
Liao, Min-Tser…[et al.]. Insulin Resistance in Patients with Chronic Kidney Disease. BioMed Research International No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-991841
American Medical Association (AMA)
Liao, Min-Tser& Sung, Chih-Chien& Hung, Kuo-Chin& Wu, Chia-Chao& Lo, Lan& Lu, Kuo-Cheng. Insulin Resistance in Patients with Chronic Kidney Disease. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-991841
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991841