Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-14
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Inflammatory bowel disease (IBD) is a complex multifactorial disease of unknown etiology.
Thus, dozens of different animal models of IBD have been developed in past decades.
Animal models of IBD are valuable and indispensable tools that provide a wide range of options for investigating involvement of various factors into the pathogenesis of IBD and to evaluate different therapeutic options.
However, the dextran sulphate sodium (DSS-) induced colitis model has some advantages when compared to other animal models of colitis.
It is well appreciated and widely used model of inflammatory bowel disease because of its simplicity.
It has many similarities to human IBD, which are mentioned in the paper.
In spite of its simplicity and wide applicability, there are also traps that need to be taken into account when using DSS model.
As demonstrated in the present paper, various factors may affect susceptibility to DSS-induced lesions and modify results.
American Psychological Association (APA)
Perše, Martina& Cerar, Anton. 2012. Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks. BioMed Research International،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-991853
Modern Language Association (MLA)
Perše, Martina& Cerar, Anton. Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks. BioMed Research International No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-991853
American Medical Association (AMA)
Perše, Martina& Cerar, Anton. Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-991853
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991853