The Plasminogen Activation System and the Regulation of Catecholaminergic Function
Joint Authors
Parmer, Robert J.
Bai, Hongdong
Nangia, Samir
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-14
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The local environment of neurosecretory cells contains the major components of the plasminogen activation system, including the plasminogen activators, tissue plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA), as well as binding sites for t-PA, the receptor for u-PA (uPAR), and also the plasminogen activator inhibitor, PAI-1.
Furthermore, these cells express specific binding sites for plasminogen, which is available in the circulation and in interstitial fluid.
Colocalization of plasminogen and its activators on cell surfaces provides a mechanism for promoting local plasminogen activation.
Plasmin is retained on the cell surface where it is protected from its inhibitor, α2-antiplasmin.
In neurosecretory cells, localized plasmin activity provides a mechanism for extracellular processing of secreted hormones.
Neurotransmitter release from catecholaminergic cells is negatively regulated by cleavage products formed by plasmin-mediated proteolysis.
Recently, we have identified a major plasminogen receptor, Plg-RKT.
We have found that Plg-RKT is highly expressed in chromaffin cells of the adrenal medulla as well as in other catecholaminergic cells and tissues.
Plg-RKT-dependent plasminogen activation plays a key role in regulating catecholaminergic neurosecretory cell function.
American Psychological Association (APA)
Bai, Hongdong& Nangia, Samir& Parmer, Robert J.. 2012. The Plasminogen Activation System and the Regulation of Catecholaminergic Function. BioMed Research International،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-991857
Modern Language Association (MLA)
Bai, Hongdong…[et al.]. The Plasminogen Activation System and the Regulation of Catecholaminergic Function. BioMed Research International No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-991857
American Medical Association (AMA)
Bai, Hongdong& Nangia, Samir& Parmer, Robert J.. The Plasminogen Activation System and the Regulation of Catecholaminergic Function. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-991857
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991857