The Plasminogen Activation System and the Regulation of Catecholaminergic Function

Joint Authors

Parmer, Robert J.
Bai, Hongdong
Nangia, Samir

Source

BioMed Research International

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-10-14

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Medicine

Abstract EN

The local environment of neurosecretory cells contains the major components of the plasminogen activation system, including the plasminogen activators, tissue plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA), as well as binding sites for t-PA, the receptor for u-PA (uPAR), and also the plasminogen activator inhibitor, PAI-1.

Furthermore, these cells express specific binding sites for plasminogen, which is available in the circulation and in interstitial fluid.

Colocalization of plasminogen and its activators on cell surfaces provides a mechanism for promoting local plasminogen activation.

Plasmin is retained on the cell surface where it is protected from its inhibitor, α2-antiplasmin.

In neurosecretory cells, localized plasmin activity provides a mechanism for extracellular processing of secreted hormones.

Neurotransmitter release from catecholaminergic cells is negatively regulated by cleavage products formed by plasmin-mediated proteolysis.

Recently, we have identified a major plasminogen receptor, Plg-RKT.

We have found that Plg-RKT is highly expressed in chromaffin cells of the adrenal medulla as well as in other catecholaminergic cells and tissues.

Plg-RKT-dependent plasminogen activation plays a key role in regulating catecholaminergic neurosecretory cell function.

American Psychological Association (APA)

Bai, Hongdong& Nangia, Samir& Parmer, Robert J.. 2012. The Plasminogen Activation System and the Regulation of Catecholaminergic Function. BioMed Research International،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-991857

Modern Language Association (MLA)

Bai, Hongdong…[et al.]. The Plasminogen Activation System and the Regulation of Catecholaminergic Function. BioMed Research International No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-991857

American Medical Association (AMA)

Bai, Hongdong& Nangia, Samir& Parmer, Robert J.. The Plasminogen Activation System and the Regulation of Catecholaminergic Function. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-991857

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-991857