Controlling Self-Renewal and Differentiation of Stem Cells via Mechanical Cues
Joint Authors
Raimondi, Manuela T.
Nava, Michele M.
Pietrabissa, Riccardo
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The control of stem cell response in vitro, including self-renewal and lineage commitment, has been proved to be directed by mechanical cues, even in the absence of biochemical stimuli.
Through integrin-mediated focal adhesions, cells are able to anchor onto the underlying substrate, sense the surrounding microenvironment, and react to its properties.
Substrate-cell and cell-cell interactions activate specific mechanotransduction pathways that regulate stem cell fate.
Mechanical factors, including substrate stiffness, surface nanotopography, microgeometry, and extracellular forces can all have significant influence on regulating stem cell activities.
In this paper, we review all the most recent literature on the effect of purely mechanical cues on stem cell response, and we introduce the concept of “force isotropy” relevant to cytoskeletal forces and relevant to extracellular loads acting on cells, to provide an interpretation of how the effects of insoluble biophysical signals can be used to direct stem cells fate in vitro.
American Psychological Association (APA)
Nava, Michele M.& Raimondi, Manuela T.& Pietrabissa, Riccardo. 2012. Controlling Self-Renewal and Differentiation of Stem Cells via Mechanical Cues. BioMed Research International،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-991901
Modern Language Association (MLA)
Nava, Michele M.…[et al.]. Controlling Self-Renewal and Differentiation of Stem Cells via Mechanical Cues. BioMed Research International No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-991901
American Medical Association (AMA)
Nava, Michele M.& Raimondi, Manuela T.& Pietrabissa, Riccardo. Controlling Self-Renewal and Differentiation of Stem Cells via Mechanical Cues. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-991901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991901