Modulation of Tight Junction Structure and Function by Kinases and Phosphatases Targeting Occludin
Joint Authors
Huber, Otmar
Dörfel, Max Johannes
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Tight junctions (TJs) typically represent the most apical contacts in epithelial and endothelial cell layers where they play an essential role in the separation of extracellular or luminal spaces from underlying tissues in the body.
Depending on the protein composition, TJs define the barrier characteristics and in addition maintain cell polarity.
Two major families of integral membrane proteins form the typical TJ strand network, the tight junction-associated MARVEL protein (TAMP) family members occludin, tricellulin, and MarvelD3 as well as a specific set of claudins.
Occludin was the first identified member of these tetraspanins and is now widely accepted as a regulator of TJ assembly and function.
Therefore, occludin itself has to be tightly regulated.
Phosphorylation of occludin appears to be of central importance in this context.
Here we want to summarize current knowledge on the kinases and phosphatases directly modifying occludin, and their role in the regulation of TJ structure, function, and dynamics.
American Psychological Association (APA)
Dörfel, Max Johannes& Huber, Otmar. 2012. Modulation of Tight Junction Structure and Function by Kinases and Phosphatases Targeting Occludin. BioMed Research International،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-991910
Modern Language Association (MLA)
Dörfel, Max Johannes& Huber, Otmar. Modulation of Tight Junction Structure and Function by Kinases and Phosphatases Targeting Occludin. BioMed Research International No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-991910
American Medical Association (AMA)
Dörfel, Max Johannes& Huber, Otmar. Modulation of Tight Junction Structure and Function by Kinases and Phosphatases Targeting Occludin. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-991910
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991910