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The Effects of Chronic Ingestion of Mercuric Chloride on Fertility and Testosterone Levels in Male Sprague Dawley Rats
Joint Authors
Heath, John C.
Abdelmageed, Y.
Braden, Tim D.
Goyal, Hari O.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Although male infertility is well researched, the effects of inorganic mercury on male reproduction and fertility are less well known.
Studies pertaining to mercury and male fertility identified reduced concentration of testosterone in the serum of male workers, a toxic influence on fertility of organic mercury compounds within concentrations at the workplace, and increased days to pregnancy.
We evaluated the effect of chronic mercuric chloride (HgCl2) exposure in male rats on reproductive endpoints.
Thirty-day old male Sprague Dawley rats (n=31) were exposed to 0.0, 1.0, or 2.0 mg/kg/day of HgCl2 via gavage.
After 60 days exposure, they were housed with nonexposed females for 21 days.
A survivor analysis revealed the exposed animals took longer to impregnate the females and had a lower rate of impregnation.
Further statistical analysis revealed a lower correlation between testicular testosterone levels and days to impregnate, and also lower sperm counts in the epididymis head and body of the exposed males.
The results indicate that HgCl2 exposure had significant adverse effects on male rat reproduction endpoints including fertility at a dose that was not clinically toxic.
American Psychological Association (APA)
Heath, John C.& Abdelmageed, Y.& Braden, Tim D.& Goyal, Hari O.. 2012. The Effects of Chronic Ingestion of Mercuric Chloride on Fertility and Testosterone Levels in Male Sprague Dawley Rats. BioMed Research International،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-991913
Modern Language Association (MLA)
Heath, John C.…[et al.]. The Effects of Chronic Ingestion of Mercuric Chloride on Fertility and Testosterone Levels in Male Sprague Dawley Rats. BioMed Research International No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-991913
American Medical Association (AMA)
Heath, John C.& Abdelmageed, Y.& Braden, Tim D.& Goyal, Hari O.. The Effects of Chronic Ingestion of Mercuric Chloride on Fertility and Testosterone Levels in Male Sprague Dawley Rats. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-991913
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991913