Identification of Physiologically Active Substances as Novel Ligands for MRGPRD
Joint Authors
Fukuchi, Keisuke
Agatsuma, Toshinori
Kaneta, Yasuyuki
Nara, Futoshi
Haga, Tatsuya
Oda, Yoko
Komori, Hironobu
Uno, Makiko
Nishimura, Satoko
Takeda, Shigeki
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Mas-related G-protein coupled receptor member D (MRGPRD) is a G protein-coupled receptor (GPCR) which belongs to the Mas-related GPCRs expressed in the dorsal root ganglia (DRG).
In this study, we investigated two novel ligands in addition to beta-alanine: (1) beta-aminoisobutyric acid, a physiologically active substance, with which possible relation to tumors has been seen together with beta-alanine; (2) diethylstilbestrol, a synthetic estrogen hormone.
In addition to the novel ligands, we found that transfection of MRGPRD leads fibroblast cells to form spheroids, which would be related to oncogenicity.
To understand the MRGPRD novel character, oncogenicity, a large chemical library was screened in order to obtain MRGPRD antagonists to utilize in exploring the character.
The antagonist in turn inhibited the spheroid proliferation that is dependent on MRGPRD signaling as well as MRGPRD signals activated by beta-alanine.
The antagonist, a small-molecule compound we found in this study, is a potential anticancer agent.
American Psychological Association (APA)
Uno, Makiko& Nishimura, Satoko& Fukuchi, Keisuke& Kaneta, Yasuyuki& Oda, Yoko& Komori, Hironobu…[et al.]. 2012. Identification of Physiologically Active Substances as Novel Ligands for MRGPRD. BioMed Research International،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-991914
Modern Language Association (MLA)
Uno, Makiko…[et al.]. Identification of Physiologically Active Substances as Novel Ligands for MRGPRD. BioMed Research International No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-991914
American Medical Association (AMA)
Uno, Makiko& Nishimura, Satoko& Fukuchi, Keisuke& Kaneta, Yasuyuki& Oda, Yoko& Komori, Hironobu…[et al.]. Identification of Physiologically Active Substances as Novel Ligands for MRGPRD. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-991914
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991914