Think Small: Zebrafish as a Model System of Human Pathology
Joint Authors
Goldsmith, J. R.
Jobin, Christian
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Although human pathologies have mostly been modeled using higher mammal systems such as mice, the lower vertebrate zebrafish has gained tremendous attention as a model system.
The advantages of zebrafish over classical vertebrate models are multifactorial and include high genetic and organ system homology to humans, high fecundity, external fertilization, ease of genetic manipulation, and transparency through early adulthood that enables powerful imaging modalities.
This paper focuses on four areas of human pathology that were developed and/or advanced significantly in zebrafish in the last decade.
These areas are (1) wound healing/restitution, (2) gastrointestinal diseases, (3) microbe-host interactions, and (4) genetic diseases and drug screens.
Important biological processes and pathologies explored include wound-healing responses, pancreatic cancer, inflammatory bowel diseases, nonalcoholic fatty liver disease, and mycobacterium infection.
The utility of zebrafish in screening for novel genes important in various pathologies such as polycystic kidney disease is also discussed.
American Psychological Association (APA)
Goldsmith, J. R.& Jobin, Christian. 2012. Think Small: Zebrafish as a Model System of Human Pathology. BioMed Research International،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-991915
Modern Language Association (MLA)
Goldsmith, J. R.& Jobin, Christian. Think Small: Zebrafish as a Model System of Human Pathology. BioMed Research International No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-991915
American Medical Association (AMA)
Goldsmith, J. R.& Jobin, Christian. Think Small: Zebrafish as a Model System of Human Pathology. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-991915
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991915