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Roles of p53 in Various Biological Aspects of Hematopoietic Stem Cells
Joint Authors
Marumoto, Tomotoshi
Tani, Kenzaburo
Nii, Takenobu
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hematopoietic stem cells (HSCs) have the capacity to self-renew as well as to differentiate into all blood cell types, and they can reconstitute hematopoiesis in recipients with bone marrow ablation.
In addition, transplantation therapy using HSCs is widely performed for the treatment of various incurable diseases such as hematopoietic malignancies and congenital immunodeficiency disorders.
For the safe and successful transplantation of HSCs, their genetic and epigenetic integrities need to be maintained properly.
Therefore, understanding the molecular mechanisms that respond to various cellular stresses in HSCs is important.
The tumor suppressor protein, p53, has been shown to play critical roles in maintenance of “cell integrity” under stress conditions by controlling its target genes that regulate cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism.
In this paper, we summarize recent reports that describe various biological functions of HSCs and discuss the roles of p53 associated with them.
American Psychological Association (APA)
Nii, Takenobu& Marumoto, Tomotoshi& Tani, Kenzaburo. 2012. Roles of p53 in Various Biological Aspects of Hematopoietic Stem Cells. BioMed Research International،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-991950
Modern Language Association (MLA)
Nii, Takenobu…[et al.]. Roles of p53 in Various Biological Aspects of Hematopoietic Stem Cells. BioMed Research International No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-991950
American Medical Association (AMA)
Nii, Takenobu& Marumoto, Tomotoshi& Tani, Kenzaburo. Roles of p53 in Various Biological Aspects of Hematopoietic Stem Cells. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-991950
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991950