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An In Vivo Rabbit Model for the Evaluation of Antimicrobial Peripherally Inserted Central Catheter to Reduce Microbial Migration and Colonization as Compared to an Uncoated PICC
Joint Authors
Giare-Patel, Kamna
Olson, Merle E.
Allan, Nicholas D.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Infection is the leading complication associated with intravascular devices, and these infections develop when a catheter becomes colonized by microorganisms.
To combat this issue, medical device manufacturers seek to provide healthcare facilities with antimicrobial medical devices to prevent or reduce the colonization.
In order to adequately evaluate these devices, an in vivo model is required to accurately assess the performance of the antimicrobial devices in a clinical setting.
The model presented herein was designed to provide a simulation of the subcutaneous tunnel environment to evaluate the ability of an antimicrobial peripherally inserted central catheter (PICC), coated with chlorhexidine based technology, to reduce microbial migration and colonization compared to an uncoated PICC.
Three samples of control, uncoated PICCs and three samples of coated PICCs were surgically tunneled into the backs of female New Zealand White rabbits.
The insertion sites were then challenged with Staphylococcus aureus at the time of implantation.
Animals were evaluated out to thirty days and sacrificed.
Complete en bloc dissection and evaluation of the catheter and surrounding tissue demonstrated that the chlorhexidine coated catheter was able to significantly reduce microbial colonization and prevent microbial migration as compared to the standard, un-treated catheter.
American Psychological Association (APA)
Allan, Nicholas D.& Giare-Patel, Kamna& Olson, Merle E.. 2012. An In Vivo Rabbit Model for the Evaluation of Antimicrobial Peripherally Inserted Central Catheter to Reduce Microbial Migration and Colonization as Compared to an Uncoated PICC. BioMed Research International،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-991953
Modern Language Association (MLA)
Allan, Nicholas D.…[et al.]. An In Vivo Rabbit Model for the Evaluation of Antimicrobial Peripherally Inserted Central Catheter to Reduce Microbial Migration and Colonization as Compared to an Uncoated PICC. BioMed Research International No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-991953
American Medical Association (AMA)
Allan, Nicholas D.& Giare-Patel, Kamna& Olson, Merle E.. An In Vivo Rabbit Model for the Evaluation of Antimicrobial Peripherally Inserted Central Catheter to Reduce Microbial Migration and Colonization as Compared to an Uncoated PICC. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-991953
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991953