Increased Expression of microRNA-17 Predicts Poor Prognosis in Human Glioma
Joint Authors
Wang, Shuai
Liang, Zhaohui
Geng, Shaomei
Ma, Shucheng
Jiao, Baohua
Lu, Shengkui
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
To investigate the clinical significance of microRNA-17 (miR-17) expression in human gliomas.
Methods.
Quantitative real-time polymerase chain reaction (qRT-PCR) analysis was used to characterize the expression patterns of miR-17 in 108 glioma and 20 normal brain tissues.
The associations of miR-17 expression with clinicopathological factors and prognosis of glioma patients were also statistically analyzed.
Results.
Compared with normal brain tissues, miR-17 expression was significantly higher in glioma tissues (P<0.001).
In addition, the increased expression of miR-17 in glioma was significantly associated with advanced pathological grade (P=0.006) and low Karnofsky performance score (KPS, P=0.01).
Moreover, Kaplan-Meier survival and Cox regression analyses showed that miR-17 overexpression (P=0.008) and advanced pathological grade (P=0.02) were independent factors predicting poor prognosis for gliomas.
Furthermore, subgroup analyses showed that miR-17 expression was significantly associated with poor overall survival in glioma patients with high pathological grades (for grade III~IV: P<0.001).
Conclusions.
Our data offer the convinced evidence that the increased expression of miR-17 may have potential value for predicting poor prognosis in glioma patients with high pathological grades, indicating that miR-17 may contribute to glioma progression and be a candidate therapeutic target for this disease.
American Psychological Association (APA)
Lu, Shengkui& Wang, Shuai& Geng, Shaomei& Ma, Shucheng& Liang, Zhaohui& Jiao, Baohua. 2012. Increased Expression of microRNA-17 Predicts Poor Prognosis in Human Glioma. BioMed Research International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-991978
Modern Language Association (MLA)
Lu, Shengkui…[et al.]. Increased Expression of microRNA-17 Predicts Poor Prognosis in Human Glioma. BioMed Research International No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-991978
American Medical Association (AMA)
Lu, Shengkui& Wang, Shuai& Geng, Shaomei& Ma, Shucheng& Liang, Zhaohui& Jiao, Baohua. Increased Expression of microRNA-17 Predicts Poor Prognosis in Human Glioma. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-991978
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991978