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Phytochemical Composition, Antioxidant Activity, and Neuroprotective Effect of Terminalia chebula Retzius Extracts
Joint Authors
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The objectives of this study were to determine phytochemical compositions, chemiluminescence antioxidant activities, and neuroprotective effects on PC12 cells for water, methanol, and 95% ethanol extracts of the air-dried fruit of Terminalia chebula Retzius.
The water extract afforded the greatest yield, and total phenolic and tannin content.
The methanol extract yielded the greatest total triterpenoid content.
Based on four chemiluminescence antioxidant assays, the three extracts showed various degrees of antioxidant activity.
The methanol extract showed good antioxidant activity based on the horseradish peroxidase-luminol-hydrogen peroxide (H2O2) assay.
The water extract appeared to have good antioxidant activities in cupric sulfate-Phen-Vc-H2O2 and luminol-H2O2 assays.
Pyrogallol-luminol assay showed the 95% ethanol extract to have good antioxidant activity.
The methanol and water extracts presented neuroprotective activities on H2O2-induced PC12 cell death at 0.5–5.0 μg/mL.
Further investigations are necessary to verify these activities in vivo.
American Psychological Association (APA)
Chang, Chia Lin& Lin, Che San. 2012. Phytochemical Composition, Antioxidant Activity, and Neuroprotective Effect of Terminalia chebula Retzius Extracts. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992009
Modern Language Association (MLA)
Chang, Chia Lin& Lin, Che San. Phytochemical Composition, Antioxidant Activity, and Neuroprotective Effect of Terminalia chebula Retzius Extracts. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-992009
American Medical Association (AMA)
Chang, Chia Lin& Lin, Che San. Phytochemical Composition, Antioxidant Activity, and Neuroprotective Effect of Terminalia chebula Retzius Extracts. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992009
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992009