![](/images/graphics-bg.png)
Effect of an Ethanol Extract of Scutellaria baicalensis on Relaxation in Corpus Cavernosum Smooth Muscle
Joint Authors
Kang, Dae Gill
Lee, Yun Jung
Li, Xiang
Oh, Hyun Cheol
Son, Su Bin
Lee, Ho Sub
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aims of study.
The aim of the present study was to investigate whether an ethanol extract of Scutellaria baicalensis (ESB) relaxes penile corpus cavernosum muscle in organ bath experiments.
Materials and methods.
Changes in tension of cavernous smooth muscle strips were determined by penile strip chamber model and in penile perfusion model.
Isolated endothelium-intact rabbit corpus cavernosum was precontracted with phenylephrine (PE) and then treated with ESB.
Results.
ESB relaxed penile smooth muscle in a dose-dependent manner, and this was inhibited by pre-treatment with NG-nitro-l-arginine methyl ester (l-NAME), a nitric oxide (NO) synthase inhibitor, and 1H-[1, 2, 4]-oxadiazolo-[4,3-α]-quinoxalin-1-one (ODQ), a soluble guanylyl cyclase (sGC) inhibitor.
ESB-induced relaxation was significantly attenuated by pretreatment with tetraethylammonium (TEA), a nonselective K+ channel blocker, and charybdotoxin, a selective Ca2+-dependent K+ channel inhibitor.
ESB increased the cGMP levels of rabbit corpus cavernosum in a concentration-dependent manner without changes in cAMP levels.
In a perfusion model of penile tissue, ESB also relaxed penile corpus cavernosum smooth muscle in a dose-dependent manner.
Conclusion.
Taken together, these results suggest that ESB relaxed rabbit cavernous smooth muscle via the NO/cGMP system and Ca2+-sensitive K+ channels in the corpus cavernosum.
American Psychological Association (APA)
Li, Xiang& Oh, Hyun Cheol& Son, Su Bin& Lee, Yun Jung& Kang, Dae Gill& Lee, Ho Sub. 2011. Effect of an Ethanol Extract of Scutellaria baicalensis on Relaxation in Corpus Cavernosum Smooth Muscle. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992048
Modern Language Association (MLA)
Li, Xiang…[et al.]. Effect of an Ethanol Extract of Scutellaria baicalensis on Relaxation in Corpus Cavernosum Smooth Muscle. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-992048
American Medical Association (AMA)
Li, Xiang& Oh, Hyun Cheol& Son, Su Bin& Lee, Yun Jung& Kang, Dae Gill& Lee, Ho Sub. Effect of an Ethanol Extract of Scutellaria baicalensis on Relaxation in Corpus Cavernosum Smooth Muscle. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992048
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992048