Protective Role of Ficus carica Stem Extract against Hepatic Oxidative Damage Induced by Methanol in Male Wistar Rats
Joint Authors
Saoudi, Mongi
El Feki, Abdelfattah
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present study was aimed to investigate the antioxidant activity of Ficus carica stem extract (FE) in methanol-induced hepatotoxicity in male Wistar rats.
The rats were divided into two batches: 16 control rats (C) drinking tap water and 16 treated rats drinking Ficus carica stem extract for six weeks.
Then, each group was divided into two subgroups, and one of them was intraperitoneally injected (i.p.) daily methanol at a dose of 2.37 g/kg body weight i.p.
for 30 days, for four weeks.
The results showed that FE was found to contain large amounts of polyphenols and carotenoids.
The treatment with methanol exhibited a significant increase of serum hepatic biochemical parameters (ALT, AST, ALP, and LDH) and hepatic lipid peroxidation.
Hepatic antioxidant enzymes, namely, SOD, CAT, and GSH-Px, were significantly decreased in methanol-treated animals.
FE treatment prior to methanol intoxication has significant role in protecting animals from methanol-induced hepatic oxidative damage.
American Psychological Association (APA)
Saoudi, Mongi& El Feki, Abdelfattah. 2011. Protective Role of Ficus carica Stem Extract against Hepatic Oxidative Damage Induced by Methanol in Male Wistar Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992053
Modern Language Association (MLA)
Saoudi, Mongi& El Feki, Abdelfattah. Protective Role of Ficus carica Stem Extract against Hepatic Oxidative Damage Induced by Methanol in Male Wistar Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-992053
American Medical Association (AMA)
Saoudi, Mongi& El Feki, Abdelfattah. Protective Role of Ficus carica Stem Extract against Hepatic Oxidative Damage Induced by Methanol in Male Wistar Rats. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992053
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992053