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Inhibitory Effect of Nelumbo nucifera (Gaertn.) on the Development of Atopic Dermatitis-Like Skin Lesions in NCNga Mice
Joint Authors
Karki, Rajendra
Jung, Myung-A
Kim, Keuk-Jun
Kim, Dong-Wook
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Atopic dermatitis (AD) is a chronic inflammatory skin disease which has a complex etiology that encompasses immunologic responses.
The study was carried out to examine the effect of Nelumbo nucifera (Gaertn.) leaf (NL) on the AD-like skin lesion induced by repeated epicutaneous application of 2,4-dinitrochlorobenzene (DNCB) on the dorsal skin of NC/Nga mice.
Three different doses of NL (5, 25, and 50 mg/mice/day) were administered orally from the day of sensitization with DNCB for 4 weeks.
The efficacy of NL was judged by histopathological examination, blood IgE level, measurement of transepidermal water loss (TEWL), scratching behavior, and skin severity score.
NL resulted in the suppression of clinical severity score, TEWL, scratching behavior, and blood IgE level.
Histopathologic analyses revealed that thickening of the epidermis and mast cell degranulation was significantly reduced in NL group.
These results suggest that NL may be a useful natural resource for the management of AD.
American Psychological Association (APA)
Karki, Rajendra& Jung, Myung-A& Kim, Keuk-Jun& Kim, Dong-Wook. 2012. Inhibitory Effect of Nelumbo nucifera (Gaertn.) on the Development of Atopic Dermatitis-Like Skin Lesions in NCNga Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992057
Modern Language Association (MLA)
Karki, Rajendra…[et al.]. Inhibitory Effect of Nelumbo nucifera (Gaertn.) on the Development of Atopic Dermatitis-Like Skin Lesions in NCNga Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-992057
American Medical Association (AMA)
Karki, Rajendra& Jung, Myung-A& Kim, Keuk-Jun& Kim, Dong-Wook. Inhibitory Effect of Nelumbo nucifera (Gaertn.) on the Development of Atopic Dermatitis-Like Skin Lesions in NCNga Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992057
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992057