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Curcumin Protects against Ovariectomy-Induced Bone Changes in Rat Model
Joint Authors
Shuid, Ahmad Nazrun
Ima-Nirwana, Soelaiman
Hussan, Farida
Ibraheem, Nawwar Ghassan
Kamarudin, Taty Anna
Othman, Faizah
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Osteoporosis is a metabolic disease affecting both men and women especially in postmenopausal women.
Curcumin possesses many medicinal properties.
In this study, thirty two female Sprague-Dawley rats were used to determine the potential effect of curcumin in prevention of bone loss following ovariectomy.
The animals were divided into Sham group, ovariectomised control, ovariectomised treated with curcumin 110 mg/kg and ovariectomised treated with Premarin 100 μg/kg.
The treatments were given via daily oral gavages for 60 days.
The structural parameters such as bone volume, trabecular number, trabecular thickness and trabecular separation were found to be deteriorated in ovariectomised rats compared to Sham group.
Moreover, the reduced osteoblast count, the increased osteoclast count and increased eroded surface were found in ovariectomised groups.
Treatment with curcumin was able to reverse all these ovariectomy-induced deteriorations.
Curcumin treatment was as effective as Premarin in most parameters except the bone volume and eroded surface, which were better than Premarin.
The high dose of curcumin treatment was not only able to reduce the osteoclast number but also increase the osteoblast count.
Therefore, the potential effect of curcumin can be applied as an alternative to oestrogen for prevention of postmenopausal osteoporosis.
American Psychological Association (APA)
Hussan, Farida& Ibraheem, Nawwar Ghassan& Kamarudin, Taty Anna& Shuid, Ahmad Nazrun& Ima-Nirwana, Soelaiman& Othman, Faizah. 2012. Curcumin Protects against Ovariectomy-Induced Bone Changes in Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992082
Modern Language Association (MLA)
Hussan, Farida…[et al.]. Curcumin Protects against Ovariectomy-Induced Bone Changes in Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-992082
American Medical Association (AMA)
Hussan, Farida& Ibraheem, Nawwar Ghassan& Kamarudin, Taty Anna& Shuid, Ahmad Nazrun& Ima-Nirwana, Soelaiman& Othman, Faizah. Curcumin Protects against Ovariectomy-Induced Bone Changes in Rat Model. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992082
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992082