The Inhibition of Spinal Astrocytic JAK2-STAT3 Pathway Activation Correlates with the Analgesic Effects of Triptolide in the Rat Neuropathic Pain Model
Joint Authors
Tang, Jun
Li, Zhi-Hong
Ge, Shun-Nan
Wang, Wei
Mei, Xiao-Peng
Wang, Wen
Zhang, Ting
Xu, Li-Xian
Li, Jin-Lian
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Neuropathic pain (NP) is an intractable clinical problem without satisfactory treatments.
However, certain natural products have been revealed as effective therapeutic agents for the management of pain states.
In this study, we used the spinal nerve ligation (SNL) pain model to investigate the antinociceptive effect of triptolide (T10), a major active component of the traditional Chinese herb Tripterygium wilfordii Hook F.
Intrathecal T10 inhibited the mechanical nociceptive response induced by SNL without interfering with motor performance.
Additionally, the anti-nociceptive effect of T10 was associated with the inhibition of the activation of spinal astrocytes.
Furthermore, intrathecal administration of T10 attenuated SNL-induced janus kinase (JAK) signal transducers and activators of transcription 3 (STAT3) signalling pathway activation and inhibited the upregulation of proinflammatory cytokines, such as interleukin-6, interleukin-1 beta, and tumour necrosis factor-α, in dorsal horn astrocytes.
Moreover, NR2B-containing spinal N-methyl D-aspartate receptor (NMDAR) was subsequently inhibited.
Above all, T10 can alleviate SNL-induced NP via inhibiting the neuroinflammation in the spinal dorsal horn.
The anti-inflammation effect of T10 may be related with the suppression of spinal astrocytic JAK-STAT3 activation.
Our results suggest that T10 may be a promising drug for the treatment of NP.
American Psychological Association (APA)
Tang, Jun& Li, Zhi-Hong& Ge, Shun-Nan& Wang, Wei& Mei, Xiao-Peng& Wang, Wen…[et al.]. 2012. The Inhibition of Spinal Astrocytic JAK2-STAT3 Pathway Activation Correlates with the Analgesic Effects of Triptolide in the Rat Neuropathic Pain Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-992090
Modern Language Association (MLA)
Tang, Jun…[et al.]. The Inhibition of Spinal Astrocytic JAK2-STAT3 Pathway Activation Correlates with the Analgesic Effects of Triptolide in the Rat Neuropathic Pain Model. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-992090
American Medical Association (AMA)
Tang, Jun& Li, Zhi-Hong& Ge, Shun-Nan& Wang, Wei& Mei, Xiao-Peng& Wang, Wen…[et al.]. The Inhibition of Spinal Astrocytic JAK2-STAT3 Pathway Activation Correlates with the Analgesic Effects of Triptolide in the Rat Neuropathic Pain Model. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-992090
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992090