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Molecular Mechanism of Isocupressic Acid Supresses MA-10 Cell Steroidogenesis
Joint Authors
Tsui, Kuan-Hao
Wang, Jyun-Yuan
Wu, Leang-Shin
Chiu, Chih-Hsien
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Consumption of ponderosa pine needles causes late-term abortions in cattle and is a serious poisonous plant problem in foothill and mountain rangelands.
Isocupressic acid (IA) is the component of pine needles responsible for the abortifacient effect, its abortifacient effect may be due to inhibition of steroidogenesis.
To investigate the more detail molecular mechanism, we used MA-10 cell, which is wild used to investigate molecular mechanism of steroidogenesis, to characterize the molecular mechanisms underlying the actions of IA in more detail.
In this report, we focus on the function of IA on important steroidogenic genes, including steroidogenic acute regulatory protein (StAR), cytochrome P450 cholesterol side-chain cleavage (P450scc), and 3β-hydroxysteroid dehydrogenase (3β-HSD).
We found that IA does not affect enzyme activities of these genes but inhibits transcription of P450scc and translation of StAR and P450scc through attenuating cAMP-PKA signaling.
Thus, steroid productions of cells were suppressed.
American Psychological Association (APA)
Tsui, Kuan-Hao& Wang, Jyun-Yuan& Wu, Leang-Shin& Chiu, Chih-Hsien. 2012. Molecular Mechanism of Isocupressic Acid Supresses MA-10 Cell Steroidogenesis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992092
Modern Language Association (MLA)
Tsui, Kuan-Hao…[et al.]. Molecular Mechanism of Isocupressic Acid Supresses MA-10 Cell Steroidogenesis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-992092
American Medical Association (AMA)
Tsui, Kuan-Hao& Wang, Jyun-Yuan& Wu, Leang-Shin& Chiu, Chih-Hsien. Molecular Mechanism of Isocupressic Acid Supresses MA-10 Cell Steroidogenesis. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992092