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Long-Term Oral Administration of Capsicum baccatum Extracts Does Not Alter Behavioral, Hematological, and Metabolic Parameters in CF1 Mice
Joint Authors
Zimmer, Aline Rigon
Leonardi, Bianca
Zimmer, Eduardo Rigon
Kalinine, Eduardo
de Souza, Diogo Onofre
Portela, Luis Valmor
Gosmann, Grace
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Our group showed that crude ethanol (CE) and butanol (BUT) extracts of Capsicum baccatum presented anti-inflammatory and antioxidant properties.
Furthermore, the flavonoid and total phenolic contents were positively correlated with both of these properties observed for C.
baccatum extracts.
The present study demonstrated that 60 days of oral administration of CE and BUT (200 mg/kg) in mice did not cause significant differences in the following parameters evaluated: hematological profile, body weight and relative weight of visceral organs, systemic lipid profile, glucose homeostasis (GTT), kidney and hepatic biochemical markers, and spontaneous locomotion and anxiety-like behavior.
Altogether, these results indicate for the first time that the long-term oral administration of C.
baccatum extracts does not affect specific aspects of CF1 mice physiology, suggesting their safety, building up the venue to test their efficacy in animal models underlying persistent activation of oxidative and inflammatory pathways.
American Psychological Association (APA)
Zimmer, Aline Rigon& Leonardi, Bianca& Zimmer, Eduardo Rigon& Kalinine, Eduardo& de Souza, Diogo Onofre& Portela, Luis Valmor…[et al.]. 2012. Long-Term Oral Administration of Capsicum baccatum Extracts Does Not Alter Behavioral, Hematological, and Metabolic Parameters in CF1 Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992099
Modern Language Association (MLA)
Zimmer, Aline Rigon…[et al.]. Long-Term Oral Administration of Capsicum baccatum Extracts Does Not Alter Behavioral, Hematological, and Metabolic Parameters in CF1 Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-992099
American Medical Association (AMA)
Zimmer, Aline Rigon& Leonardi, Bianca& Zimmer, Eduardo Rigon& Kalinine, Eduardo& de Souza, Diogo Onofre& Portela, Luis Valmor…[et al.]. Long-Term Oral Administration of Capsicum baccatum Extracts Does Not Alter Behavioral, Hematological, and Metabolic Parameters in CF1 Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992099
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992099