Propolis Prevents Hepatorenal Injury Induced by Chronic Exposure to Carbon Tetrachloride
Author
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Carbon tetrachloride (CCl4) is a well-known hepatotoxicant, and its exposure induces hepatorenal injury via oxidative stress and biochemical alterations.
This study had been conducted to confirm the protective role of propolis extract on CCl4-induced hepatorenal oxidative stress and resultant injury.
Propolis extracts collected from Gwalior district and 24 female Sprague Dawley rats were used for experiment.
Animals were exposed to CCl4 (0.15 mL/kg, i.p.) for 12 weeks (5 days/week) followed by treatment with propolis extract (200 mg/kg, p.o.) for consecutive 2 weeks.
CCl4 exposure significantly depleted blood sugar and hemoglobin level and raised the level of transaminases, alkaline phosphatase, lactate dehydrogenase, protein, urea, albumin, bilirubin, creatinine, triglycerides, and cholesterol in serum.
Lipid peroxidation was enhanced, whereas GSH was decreased significantly in liver and kidney in CCl4-intoxicated group.
Ethanolic extract of propolis successfully prevented these alterations in experimental animals.
Activities of catalase, adenosine triphosphatase, glucose-6-phosphatase, acid, and alkaline phosphatase were also maintained towards normal with propolis therapy.
Light microscopical studies showed considerable protection in liver and kidney with propolis treatment, thus, substantiated biochemical observations.
This study confirmed hepatoprotective potential of propolis extract against chronic injury induced by CCl4 by regulating antioxidative defense activities.
American Psychological Association (APA)
Bhadauria, Monika. 2011. Propolis Prevents Hepatorenal Injury Induced by Chronic Exposure to Carbon Tetrachloride. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992118
Modern Language Association (MLA)
Bhadauria, Monika. Propolis Prevents Hepatorenal Injury Induced by Chronic Exposure to Carbon Tetrachloride. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-992118
American Medical Association (AMA)
Bhadauria, Monika. Propolis Prevents Hepatorenal Injury Induced by Chronic Exposure to Carbon Tetrachloride. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992118
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992118