Cyprinus carpio Decoction Improves Nutrition and Immunity and Reduces Proteinuria through Nephrin and CD2AP Expressions in Rats with Adriamycin-Induced Nephropathy
Joint Authors
Qi, Yumei
Xiao, Huijuan
Xu, Changjie
Tian, Xiaojian
Wu, Hui
Shen, Wei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cyprinus carpio decoction (CCD) is a well-known Chinese food medicine formula, accepted widely as a useful therapy in preventing edema and proteinuria caused by renal disease.
However, the mechanism underlying this effect remains unclear.
The current study investigated the potential mechanism of CCD in alleviating nephropathy induced by adriamycin (ADR) in rats.
70 eight-week-old Wistar rats were randomly divided into normal, model, fosinopril, YD, YG groups.
All rats except for the normal group received 6.5 mg/kg·bw of ADR injection into the vena caudalis once.
Different doses of CCD (11.3 and 22.5 g kg−1) were lavaged to rats in YD and YG groups, respectively.
Then the serum biochemical values of the total protein (TP), albumin (ALB), blood urea nitrogen (BUN), creatinine (Cr), electrolyte levels, and the urinary protein (UP) content in 12 hr urine were measured.
Interleukin-4 (IL-4) and interferon (INF-γ) were measured by enzyme-like immunosorbent assay (ELISA).
The pathomorphological analysis was observed using light and electron microscopy, and the expressions of nephrin and CD2-associated protein (CD2AP) in renal tissues were determined by immunohistochemical assay.
The results indicated that CCD can relieve ADR-induced nephropathy (ADN) by improving the nutrition status, regulating the immunity, and inhibiting proteinuria by increasing nephrin and CD2AP expressions.
American Psychological Association (APA)
Qi, Yumei& Xiao, Huijuan& Xu, Changjie& Tian, Xiaojian& Wu, Hui& Shen, Wei. 2012. Cyprinus carpio Decoction Improves Nutrition and Immunity and Reduces Proteinuria through Nephrin and CD2AP Expressions in Rats with Adriamycin-Induced Nephropathy. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992122
Modern Language Association (MLA)
Qi, Yumei…[et al.]. Cyprinus carpio Decoction Improves Nutrition and Immunity and Reduces Proteinuria through Nephrin and CD2AP Expressions in Rats with Adriamycin-Induced Nephropathy. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-992122
American Medical Association (AMA)
Qi, Yumei& Xiao, Huijuan& Xu, Changjie& Tian, Xiaojian& Wu, Hui& Shen, Wei. Cyprinus carpio Decoction Improves Nutrition and Immunity and Reduces Proteinuria through Nephrin and CD2AP Expressions in Rats with Adriamycin-Induced Nephropathy. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992122
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992122