Comparative Effects of Er-Xian Decoction, Epimedium Herbs, and Icariin with Estrogen on Bone and Reproductive Tissue in Ovariectomized Rats
Joint Authors
Xue, Liming
Wang, Yin
Jiang, Yiping
Han, Ting
Nie, Yan
Zhao, Lu
Zhang, Qiaoyan
Qin, Luping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Er-Xian Decoction (EXD), Epimedium herbs (herbs of Epimedium brevicornum Maxim, EBH), and icariin (ICA) have been proven to have estrogen-like and antiosteoporotic activity and are used for the treatment of osteoporosis, menopausal syndrome, and age-associated diseases.
The present study found that EXD, EBH, and ICA treatments, emulating estrogen, significantly contributed to bone density and architecture in OVX rats and that EXD is similar to estrogen and exerts a concomitant effect on bone formation and bone resorption at the tissue level, while EBH and ICA produced bone-protective effects mainly by inhibiting bone resorption.
Nevertheless, EXD, EBH, and ICA treatments manifested a fewer adverse effects on the uterus, mammary gland, and vagina compared to estrogen administrations.
Among the EXD, EBH, and ICA, EXD was found to have superior efficacy and safety profile.
American Psychological Association (APA)
Xue, Liming& Wang, Yin& Jiang, Yiping& Han, Ting& Nie, Yan& Zhao, Lu…[et al.]. 2012. Comparative Effects of Er-Xian Decoction, Epimedium Herbs, and Icariin with Estrogen on Bone and Reproductive Tissue in Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-992126
Modern Language Association (MLA)
Xue, Liming…[et al.]. Comparative Effects of Er-Xian Decoction, Epimedium Herbs, and Icariin with Estrogen on Bone and Reproductive Tissue in Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-992126
American Medical Association (AMA)
Xue, Liming& Wang, Yin& Jiang, Yiping& Han, Ting& Nie, Yan& Zhao, Lu…[et al.]. Comparative Effects of Er-Xian Decoction, Epimedium Herbs, and Icariin with Estrogen on Bone and Reproductive Tissue in Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-992126
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992126