Effect of Toki-Shakuyaku-San on Regional Cerebral Blood Flow in Patients with Mild Cognitive Impairment and Alzheimer's Disease
Joint Authors
Matsuoka, Teruyuki
Narumoto, Jin
Shibata, Keisuke
Okamura, Aiko
Taniguchi, Shogo
Kitabayashi, Yurinosuke
Fukui, Kenji
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The aim of this study was to examine the effect of toki-shakuyaku-san (TSS) on mild cognitive impairment (MCI) and Alzheimer's disease (AD) using single-photon emission computed tomography (SPECT).
All subjects were administered TSS (7.5 g/day) for eight weeks.
SPECT and evaluations using the Mini Mental State Examination (MMSE), Neuropsychiatric Inventory, and Physical Self-Maintenance Scale were performed before and after treatment with TSS.
Three patients with MCI and five patients with AD completed the study.
No adverse events occurred during the study period.
After treatment with TSS, regional cerebral blood flow (rCBF) in the posterior cingulate was significantly higher than that before treatment.
No brain region showed a significant decrease in rCBF.
TSS treatment also tended to improve the score for orientation to place on the MMSE.
These results suggest that TSS could be useful for treatment of MCI and AD.
American Psychological Association (APA)
Matsuoka, Teruyuki& Narumoto, Jin& Shibata, Keisuke& Okamura, Aiko& Taniguchi, Shogo& Kitabayashi, Yurinosuke…[et al.]. 2012. Effect of Toki-Shakuyaku-San on Regional Cerebral Blood Flow in Patients with Mild Cognitive Impairment and Alzheimer's Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-992129
Modern Language Association (MLA)
Matsuoka, Teruyuki…[et al.]. Effect of Toki-Shakuyaku-San on Regional Cerebral Blood Flow in Patients with Mild Cognitive Impairment and Alzheimer's Disease. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-992129
American Medical Association (AMA)
Matsuoka, Teruyuki& Narumoto, Jin& Shibata, Keisuke& Okamura, Aiko& Taniguchi, Shogo& Kitabayashi, Yurinosuke…[et al.]. Effect of Toki-Shakuyaku-San on Regional Cerebral Blood Flow in Patients with Mild Cognitive Impairment and Alzheimer's Disease. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-992129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992129