Lignosus rhinocerus (Cooke) Ryvarden: A Medicinal Mushroom That Stimulates Neurite Outgrowth in PC-12 Cells
Joint Authors
David, Pamela
Tan, Yee-Shin
Eik, Lee-Fang
Wong, Kah-Hui
Naidu, Murali
Sabaratnam, Vikineswary
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A national treasure mushroom, Lignosus rhinocerus, has been used to treat variety of ailments by local and indigenous communities in Malaysia.
The aim of this study was to investigate the potential of the most valuable part of L.
rhinocerus, the sclerotium, on neurite outgrowth activity by using PC-12Adh cell line.
Differentiated cells with one thin extension at least double the length of the cell diameter were scored positive.
Our results showed that aqueous sclerotium L.
rhinocerus extract induced neurite outgrowths of 24.4% and 42.1% at 20 μg/mL (w/v) of aqueous extract alone and a combination of 20 μg/mL (w/v) aqueous extract and 30 ng/mL (w/v) of NGF, respectively.
Combination of NGF and sclerotium extract had additive effects and enhanced neurite outgrowth.
Neuronal differentiation was demonstrated by indirect immunofluorescence of neurofilament protein.
Aqueous sclerotium extract contained neuroactive compounds that stimulated neurite outgrowth in vitro.
To our knowledge this is the first report on neurite-stimulating activities of L.
rhinocerus.
American Psychological Association (APA)
Eik, Lee-Fang& Naidu, Murali& David, Pamela& Wong, Kah-Hui& Tan, Yee-Shin& Sabaratnam, Vikineswary. 2011. Lignosus rhinocerus (Cooke) Ryvarden: A Medicinal Mushroom That Stimulates Neurite Outgrowth in PC-12 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992194
Modern Language Association (MLA)
Eik, Lee-Fang…[et al.]. Lignosus rhinocerus (Cooke) Ryvarden: A Medicinal Mushroom That Stimulates Neurite Outgrowth in PC-12 Cells. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-992194
American Medical Association (AMA)
Eik, Lee-Fang& Naidu, Murali& David, Pamela& Wong, Kah-Hui& Tan, Yee-Shin& Sabaratnam, Vikineswary. Lignosus rhinocerus (Cooke) Ryvarden: A Medicinal Mushroom That Stimulates Neurite Outgrowth in PC-12 Cells. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992194
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992194