Effects of Lipid Regulation Using Raw and Processed Radix Polygoni Multiflori in Rats Fed a High-Fat Diet
Joint Authors
Li, Na
Chen, Zhen
Mao, Xiaojian
Yu, Jie
Zhao, Ronghua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Raw and processed Radix Polygoni Multiflori have been used in the prevention and treatment of nonalcoholic fatty liver disease (NAFLD), hyperlipidemia, and related diseases in Asian counties for centuries.
The lipid regulation ability of raw and processed Poligoni Multiflori Radix were compared in high-fat diet fed rats in this research.
Total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) in blood and liver tissue were all significantly higher in model rats.
However, triglyceride (TG) contents increased only in liver tissue, not in the blood samples.
The rats fed the high-fat diets were considered the model of type IIa hyperlipidemia and early-stage nonalcoholic fatty liver disease.
Both Radix Polygoni Multiflori (RPM) and Radix Polygoni Multiflori Praeparata (RPMP) revealed TC-lowing effects, and middling doses of RPMP displayed the most significant TC-lowing effects, as indicated by blood samples.
Neither RPM nor RPMP was found to reduce LDL-C in rats' blood.
Nevertheless, RPM showed dose-dependent TC- and TG-lowing effects in the liver tissue samples.
In conclusion, RPM showed more pronounced effects on lipid regulation in liver samples in the treatment of early-stage NAFLD.
RPMP, however, displayed better effects in regulating lipids in circulating blood for the treatment of hyperlipidemia.
American Psychological Association (APA)
Li, Na& Chen, Zhen& Mao, Xiaojian& Yu, Jie& Zhao, Ronghua. 2012. Effects of Lipid Regulation Using Raw and Processed Radix Polygoni Multiflori in Rats Fed a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992201
Modern Language Association (MLA)
Li, Na…[et al.]. Effects of Lipid Regulation Using Raw and Processed Radix Polygoni Multiflori in Rats Fed a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-992201
American Medical Association (AMA)
Li, Na& Chen, Zhen& Mao, Xiaojian& Yu, Jie& Zhao, Ronghua. Effects of Lipid Regulation Using Raw and Processed Radix Polygoni Multiflori in Rats Fed a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992201