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Luteolin Suppresses Inflammatory Mediator Expression by Blocking the AktNFκB Pathway in Acute Lung Injury Induced by Lipopolysaccharide in Mice
Joint Authors
Li, Yi-Ching
Yeh, Chung-Hsin
Yang, Ming-Ling
Kuan, Yu-Hsiang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Acute lung injury (ALI), instilled by lipopolysaccharide (LPS), is a severe illness with excessive mortality and has no specific treatment strategy.
Luteolin is an anti-inflammatory flavonoid and widely distributed in the plants.
Pretreatment with luteolin inhibited LPS-induced histological changes of ALI and lung tissue edema.
In addition, LPS-induced inflammatory responses, including increased vascular permeability, tumor necrosis factor (TNF)-α and interleukin (IL)-6 production, and expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), were also reduced by luteolin in a concentration-dependent manner.
Furthermore, luteolin suppressed activation of NFκB and its upstream molecular factor, Akt.
These results suggest that the protection mechanism of luteolin is by inhibition of NFκB activation possibly via Akt.
American Psychological Association (APA)
Li, Yi-Ching& Yeh, Chung-Hsin& Yang, Ming-Ling& Kuan, Yu-Hsiang. 2011. Luteolin Suppresses Inflammatory Mediator Expression by Blocking the AktNFκB Pathway in Acute Lung Injury Induced by Lipopolysaccharide in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992239
Modern Language Association (MLA)
Li, Yi-Ching…[et al.]. Luteolin Suppresses Inflammatory Mediator Expression by Blocking the AktNFκB Pathway in Acute Lung Injury Induced by Lipopolysaccharide in Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-992239
American Medical Association (AMA)
Li, Yi-Ching& Yeh, Chung-Hsin& Yang, Ming-Ling& Kuan, Yu-Hsiang. Luteolin Suppresses Inflammatory Mediator Expression by Blocking the AktNFκB Pathway in Acute Lung Injury Induced by Lipopolysaccharide in Mice. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992239
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992239