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Single Agent Polysaccharopeptide Delays Metastases and Improves Survival in Naturally Occurring Hemangiosarcoma
Joint Authors
Brown, Dorothy Cimino
Reetz, Jennifer
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The 2008 World Health Organization World Cancer Report describes global cancer incidence soaring with many patients living in countries that lack resources for cancer control.
Alternative treatment strategies that can reduce the global disease burden at manageable costs must be developed.
Polysaccharopeptide (PSP) is the bioactive agent from the mushroom Coriolus versicolor.
Studies indicate PSP has in vitro antitumor activities and inhibits the growth of induced tumors in animal models.
Clear evidence of clinically relevant benefits of PSP in cancer patients, however, is lacking.
The investment of resources required to complete large-scale, randomized controlled trials of PSP in cancer patients is more easily justified if antitumor and survival benefits are documented in a complex animal model of a naturally occurring cancer that parallels human disease.
Because of its high metastatic rate and vascular origin, canine hemangiosarcoma is used for investigations in antimetastatic and antiangiogenic therapies.
In this double-blind randomized multidose pilot study, high-dose PSP significantly delayed the progression of metastases and afforded the longest survival times reported in canine hemangiosarcoma.
These data suggest that, for those cancer patients for whom advanced treatments are not accessible, PSP as a single agent might offer significant improvements in morbidity and mortality.
American Psychological Association (APA)
Brown, Dorothy Cimino& Reetz, Jennifer. 2012. Single Agent Polysaccharopeptide Delays Metastases and Improves Survival in Naturally Occurring Hemangiosarcoma. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992240
Modern Language Association (MLA)
Brown, Dorothy Cimino& Reetz, Jennifer. Single Agent Polysaccharopeptide Delays Metastases and Improves Survival in Naturally Occurring Hemangiosarcoma. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-992240
American Medical Association (AMA)
Brown, Dorothy Cimino& Reetz, Jennifer. Single Agent Polysaccharopeptide Delays Metastases and Improves Survival in Naturally Occurring Hemangiosarcoma. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992240