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Demethoxycurcumin Retards Cell Growth and Induces Apoptosis in Human Brain Malignant Glioma GBM 8401 Cells
Joint Authors
Huang, Tzuu-Yuan
Hsu, Che-Wen
Chang, Weng-Cheng
Wang, Miin-Yau
Wu, June-Fu
Hsu, Yi-Chiang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Demethoxycurcumin (DMC; a curcumin-related demethoxy compound) has been recently shown to display antioxidant and antitumor activities.
It has also produced a potent chemopreventive action against cancer.
In the present study, the antiproliferation (using the MTT assay, DMC was found to have cytotoxic activities against GBM 8401 cell with IC50 values at 22.71 μM) and induced apoptosis effects of DMC have been investigated in human brain malignant glioma GBM 8401 cells.
We have studied the mitochondrial membrane potential (MMP), DNA fragmentation, caspase activation, and NF-κB transcriptional factor activity.
By these approaches, our results indicated that DMC has produced an inhibition of cell proliferation as well as the activation of apoptosis in GBM 8401 cells.
Both effects were observed to increase in proportion with the dosage of DMC treatment, and the apoptosis was induced by DMC in human brain malignant glioma GBM 8401 cells via mitochondria- and caspase-dependent pathways.
American Psychological Association (APA)
Huang, Tzuu-Yuan& Hsu, Che-Wen& Chang, Weng-Cheng& Wang, Miin-Yau& Wu, June-Fu& Hsu, Yi-Chiang. 2012. Demethoxycurcumin Retards Cell Growth and Induces Apoptosis in Human Brain Malignant Glioma GBM 8401 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-992246
Modern Language Association (MLA)
Huang, Tzuu-Yuan…[et al.]. Demethoxycurcumin Retards Cell Growth and Induces Apoptosis in Human Brain Malignant Glioma GBM 8401 Cells. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-992246
American Medical Association (AMA)
Huang, Tzuu-Yuan& Hsu, Che-Wen& Chang, Weng-Cheng& Wang, Miin-Yau& Wu, June-Fu& Hsu, Yi-Chiang. Demethoxycurcumin Retards Cell Growth and Induces Apoptosis in Human Brain Malignant Glioma GBM 8401 Cells. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-992246
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992246