Oroxylin A, but Not Vasopressin, Ameliorates Cardiac Dysfunction of Endotoxemic Rats
Joint Authors
Liu, Chin-Hung
Chen, Mei-Fang
Tseng, Tzu-Ling
Chen, Lih-Geeng
Kuo, Jon-Son
Lee, Tony Jer-Fu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The mortality in septic patients with myocardial dysfunction is higher than those without it.
Beneficial effects of flavonoid oroxylin A (Oro-A) on endotoxemic hearts were evaluated and compared with that of arginine vasopressin (AVP) which is used to reverse hypotension in septic patients.
Endotoxemia in rats was induced by one-injection of lipopolysaccharides (LPS, 10 mg/kg, i.p.), and hearts were isolated 5-hrs or 16-hrs later.
Isolated hearts with constant-pressure or constant-flow mode were examined by Langendorff technique.
Rate and force of contractions of isolated atrial and ventricular strips were examined by tissue myography.
Isolated endotoxemic hearts were characterized by decreased or increased coronary flow (CF) in LPS-treated-for-5hr and LPS-treated-for-16-hr groups, respectively, with decreased inotropy in both groups.
Oro-A-perfusion ameliorated while AVP-perfusion worsened the decreased CF and inotropy in both preparations.
Oro-A and AVP, however, did not affect diminished force or rate of contraction of atrial and ventricular strips of endotoxemic hearts.
Oro-A-induced CF increase was not affected following coronary endothelium-denudation with saponin.
These results suggest that Oro-A ameliorates LPS-depressed cardiac functions by increasing CF, leading to positive inotropy.
In contrast, AVP aggravates cardiac dysfunction by decreasing CF.
Oro-A is a potentially useful candidate for treating endotoxemia complicated with myocardial dysfunction.
American Psychological Association (APA)
Liu, Chin-Hung& Chen, Mei-Fang& Tseng, Tzu-Ling& Chen, Lih-Geeng& Kuo, Jon-Son& Lee, Tony Jer-Fu. 2012. Oroxylin A, but Not Vasopressin, Ameliorates Cardiac Dysfunction of Endotoxemic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992253
Modern Language Association (MLA)
Liu, Chin-Hung…[et al.]. Oroxylin A, but Not Vasopressin, Ameliorates Cardiac Dysfunction of Endotoxemic Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-992253
American Medical Association (AMA)
Liu, Chin-Hung& Chen, Mei-Fang& Tseng, Tzu-Ling& Chen, Lih-Geeng& Kuo, Jon-Son& Lee, Tony Jer-Fu. Oroxylin A, but Not Vasopressin, Ameliorates Cardiac Dysfunction of Endotoxemic Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992253