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Efficacy of Bidens pilosa Extract against Herpes Simplex Virus Infection In Vitro and In Vivo
Joint Authors
Nakama, Shinji
Tamaki, Kazumi
Ishikawa, Chie
Tadano, Masayuki
Mori, Naoki
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The development of strains of herpes simplex virus (HSV) resistant to drugs has been reported among the immunocompromised patients.
Thus, there is a need to develop new therapeutic agents for HSV infections.
We evaluated the anti-HSV activity of Bidens pilosa (B.
pilosa), a tropical weed, in tissue culture cells and a mouse model.
B.
pilosa extract showed potent virucidal activity.
It inhibited plaque formation and suppressed virus yield in Vero and RAW 264.7 cells infected with HSV-1 and HSV-2.
Both the binding of virus to host cells and penetration of virus into cells were also blocked by B.
pilosa.
Furthermore, B.
pilosa was effective against thymidine kinase-deficient and phosphonoacetate-resistant HSV-1 strains.
B.
pilosa treatment increased the survival rate of HSV-infected mice and limited the development of skin lesions.
Our results indicate that B.
pilosa has anti-HSV activity and is thus a potentially useful medical plant for treatment of HSV infection.
American Psychological Association (APA)
Nakama, Shinji& Tamaki, Kazumi& Ishikawa, Chie& Tadano, Masayuki& Mori, Naoki. 2012. Efficacy of Bidens pilosa Extract against Herpes Simplex Virus Infection In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992260
Modern Language Association (MLA)
Nakama, Shinji…[et al.]. Efficacy of Bidens pilosa Extract against Herpes Simplex Virus Infection In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-992260
American Medical Association (AMA)
Nakama, Shinji& Tamaki, Kazumi& Ishikawa, Chie& Tadano, Masayuki& Mori, Naoki. Efficacy of Bidens pilosa Extract against Herpes Simplex Virus Infection In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992260
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992260