Anti-Inflammatory Activities of Cinnamomum cassia Constituents In Vitro and In Vivo
Joint Authors
Huang, Shyh-Shyun
Liao, Jung-Chun
Deng, Jeng-Shyan
Huang, Guan-Jhong
Chiu, Chuan-Sung
Shie, Pei-Hsin
Hou, Wen-Chi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
We have investigated the anti-inflammatory effects of Cinnamomum cassia constituents (cinnamic aldehyde, cinnamic alcohol, cinnamic acid, and coumarin) using lipopolysaccharide (LPS)-stimulated mouse macrophage (RAW264.7) and carrageenan (Carr)-induced mouse paw edema model.
When RAW264.7 macrophages were treated with cinnamic aldehyde together with LPS, a significant concentration-dependent inhibition of nitric oxide (NO), tumor necrosis factor (TNF-α), and prostaglandin E2 (PGE2) levels productions were detected.
Western blotting revealed that cinnamic aldehyde blocked protein expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), nuclear transcription factor kappa B (NF-κB), and IκBα, significantly.
In the anti-inflammatory test, cinnamic aldehyde decreased the paw edema after Carr administration, and increased the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the paw tissue.
We also demonstrated cinnamic aldehyde attenuated the malondialdehyde (MDA) level and myeloperoxidase (MPO) activity in the edema paw after Carr injection.
Cinnamic aldehyde decreased the NO, TNF-α, and PGE2 levels on the serum level after Carr injection.
Western blotting revealed that cinnamic aldehyde decreased Carr-induced iNOS, COX-2, and NF-κB expressions in the edema paw.
These findings demonstrated that cinnamic aldehyde has excellent anti-inflammatory activities and thus has great potential to be used as a source for natural health products.
American Psychological Association (APA)
Liao, Jung-Chun& Deng, Jeng-Shyan& Chiu, Chuan-Sung& Hou, Wen-Chi& Huang, Shyh-Shyun& Shie, Pei-Hsin…[et al.]. 2012. Anti-Inflammatory Activities of Cinnamomum cassia Constituents In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992282
Modern Language Association (MLA)
Liao, Jung-Chun…[et al.]. Anti-Inflammatory Activities of Cinnamomum cassia Constituents In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-992282
American Medical Association (AMA)
Liao, Jung-Chun& Deng, Jeng-Shyan& Chiu, Chuan-Sung& Hou, Wen-Chi& Huang, Shyh-Shyun& Shie, Pei-Hsin…[et al.]. Anti-Inflammatory Activities of Cinnamomum cassia Constituents In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992282
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992282