A Comparison of Wound Healing Rate Following Treatment with Aftamed and Chlorine Dioxide Gels in Streptozotocin-Induced Diabetic Rats
Joint Authors
al-Bayaty, Fouad
Abdulla, Mahmood Ameen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background and Purpose.
This study aimed to evaluate the wound healing activities of Aftamed and chlorine dioxide gels in streptozotocin-induced diabetic rats.
Experimental Approach.
Forty-eight Sprague Dawley rats were chosen for this study, divided into 4 groups.
Diabetes was induced.
Two-centimeter-diameter full-thickness skin excision wounds were created.
Animals were topically treated twice daily.
Groups 1, the diabetic control group, were treated with 0.2 mL of sterile distilled water.
Group 2 served as a reference standard were treated with 0.2 mL of Intrasite gel.
Groups 3 and 4 were treated with 0.2 mL of Aftamed and 0.2 mL of chlorine dioxide gels respectively.
Granulation tissue was excised on the 10th day and processed for histological and biochemical analysis.
The glutathione peroxidase ,superoxide dismutase activities and the malondialdehyde (MDA) levels were determined.
Results.
Aftamed-treated wounds exhibited significant increases in hydroxyproline, cellular proliferation, the number of blood vessels, and the level of collagen synthesis.
Aftamed induced an increase in the free radical-scavenging enzyme activity and significantly reduced the lipid peroxidation levels in the wounds as measured by the reduction in the MDA level.
Conclusions.
This study showed that Aftamed gel is able to significantly accelerate the process of wound healing in diabetic rats.
American Psychological Association (APA)
al-Bayaty, Fouad& Abdulla, Mahmood Ameen. 2012. A Comparison of Wound Healing Rate Following Treatment with Aftamed and Chlorine Dioxide Gels in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992313
Modern Language Association (MLA)
al-Bayaty, Fouad& Abdulla, Mahmood Ameen. A Comparison of Wound Healing Rate Following Treatment with Aftamed and Chlorine Dioxide Gels in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-992313
American Medical Association (AMA)
al-Bayaty, Fouad& Abdulla, Mahmood Ameen. A Comparison of Wound Healing Rate Following Treatment with Aftamed and Chlorine Dioxide Gels in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992313
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992313