Chemical Composition, Toxicity and Vasodilatation Effect of the Flowers Extract of Jasminum sambac (L.) Ait. “G. Duke of Tuscany”
Joint Authors
Kunhachan, Phanukit
Banchonglikitkul, Chuleratana
Kajsongkram, Tanwarat
Khayungarnnawee, Amonrat
Leelamanit, Wichet
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Phytochemical analysis of the ethanolic Jasmine flower extract of Jasminum sambac (L.) Ait.
“G.
Duke of Tuscany” revealed the mixtures of coumarins, cardiac glycosides, essential oils, flavonoids, phenolics, saponins, and steroids.
However, alkaloids, anthraquinones, and tannins were not detected.
By intravenous injection at a single dose of 0.5 mL/mouse (15 mg) of the flower extract, no systemic biological toxicity demonstrated in ICR mice was observed.
In Wistar rats, the LD50 of the extract was higher than 5,000 mg/kg BW by oral administration.
Vasodilatation effect of the 95% ethanolic extract on isolated aortic rats was also investigated.
Compared with the control group, the Jasmine flowers extract in 0.05% DMSO clearly reduced tonus of isolated endothelium thoracic aortic rings preconstricted with phenylephrine (10−6 M), as a dose-dependent manner.
Nevertheless, this pharmacological effect disappeared after the preincubation of the rings with atropine (10−6 M) or with Nω-nitro-L-arginine (10−4 M).
These are possibly due to the actions of the active components on the vessel muscarinic receptors or by causing the release of nitric oxide.
American Psychological Association (APA)
Kunhachan, Phanukit& Banchonglikitkul, Chuleratana& Kajsongkram, Tanwarat& Khayungarnnawee, Amonrat& Leelamanit, Wichet. 2012. Chemical Composition, Toxicity and Vasodilatation Effect of the Flowers Extract of Jasminum sambac (L.) Ait. “G. Duke of Tuscany”. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992314
Modern Language Association (MLA)
Kunhachan, Phanukit…[et al.]. Chemical Composition, Toxicity and Vasodilatation Effect of the Flowers Extract of Jasminum sambac (L.) Ait. “G. Duke of Tuscany”. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-992314
American Medical Association (AMA)
Kunhachan, Phanukit& Banchonglikitkul, Chuleratana& Kajsongkram, Tanwarat& Khayungarnnawee, Amonrat& Leelamanit, Wichet. Chemical Composition, Toxicity and Vasodilatation Effect of the Flowers Extract of Jasminum sambac (L.) Ait. “G. Duke of Tuscany”. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992314
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992314