Therapeutic Effects of Cortex acanthopanacis Aqueous Extract on Bone Metabolism of Ovariectomized Rats
Joint Authors
Zhang, Zhiguo
Dong, Jiazi
Liu, Meijie
Li, Yan
Pan, Jinghua
Liu, Hong
Wang, Wenlai
Bai, Dong
Xiang, Lihua
Xiao, Gary G.
Ju, Dahong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this study was to evaluate effects of aqueous extract from Cortex acanthopanacis (CAE) on osteoporosis rats induced by ovariectomy (OVX) using aqueous extract from Folium Epimedii (FEE) as positive control agent.
Three-month-old female rats that underwent OVX were treated with CAE.
After 12 weeks, bone mineral density (BMD) and indices of bone histomorphometry of tibia were measured.
Levels of protein and mRNA expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kappa-B ligand (RANKL) in tibia were evaluated.
In addition, the serum concentrations of osteocalcin (OC), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), calcitonin (CT), and parathyroid hormone (PTH) were determined.
Administration of CAE significantly prevented OVX-induced rats from gain of the body weight.
Treatment with CAE increased bone mass remarkably and showed a significant inhibitory effect on bone resorption by downregulating significantly the expression of RANKL in tibia of OVX rats.
Meanwhile, treatment of CAE significantly reduced serum level of IL-1β and increased level of CT in OVX rats.
This suggests that CAE has the potential to be used as an alternative therapeutic agent for postmenopausal osteoporosis.
American Psychological Association (APA)
Zhang, Zhiguo& Dong, Jiazi& Liu, Meijie& Li, Yan& Pan, Jinghua& Liu, Hong…[et al.]. 2012. Therapeutic Effects of Cortex acanthopanacis Aqueous Extract on Bone Metabolism of Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992345
Modern Language Association (MLA)
Zhang, Zhiguo…[et al.]. Therapeutic Effects of Cortex acanthopanacis Aqueous Extract on Bone Metabolism of Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-992345
American Medical Association (AMA)
Zhang, Zhiguo& Dong, Jiazi& Liu, Meijie& Li, Yan& Pan, Jinghua& Liu, Hong…[et al.]. Therapeutic Effects of Cortex acanthopanacis Aqueous Extract on Bone Metabolism of Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992345
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992345