It Is Not Just Folklore: The Aqueous Extract of Mung Bean Coat Is Protective against Sepsis
Joint Authors
Zhu, Shu
Li, Wei
Li, Jianhua
Jundoria, Arvin
Sama, Andrew E.
Wang, Haichao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Mung bean (Vigna Radiata) has been traditionally used in China both as nutritional food and herbal medicine against a number of inflammatory conditions since the 1050s.
A nucleosomal protein, HMGB1, has recently been established as a late mediator of lethal systemic inflammation with a relatively wider therapeutic window for pharmacological interventions.
Here we explored the HMGB1-inhibiting capacity and therapeutic potential of mung bean coat (MBC) extract in vitro and in vivo.
We found that MBC extract dose-dependently attenuated LPS-induced release of HMGB1 and several chemokines in macrophage cultures.
Oral administration of MBC extract significantly increased animal survival rates from 29.4% (in saline group, N=17 mice) to 70% (in experimental MBC extract group, N=17 mice, P<0.05).
In vitro, MBC extract stimulated HMGB1 protein aggregation and facilitated both the formation of microtubule-associatedprotein-1-light-chain-3-(LC3-)containing cytoplasmic vesicles, and the production of LC3-II in macrophage cultures.
Consequently, MBC extract treatment led to reduction of cellular HMGB1 levels in macrophage cultures, which was impaired by coaddition of two autophagy inhibitors (bafilomycin A1 and 3-methyladenine).
Conclusion.
MBC extract is protective against lethal sepsis possibly by stimulating autophagic HMGB1 degradation.
American Psychological Association (APA)
Zhu, Shu& Li, Wei& Li, Jianhua& Jundoria, Arvin& Sama, Andrew E.& Wang, Haichao. 2012. It Is Not Just Folklore: The Aqueous Extract of Mung Bean Coat Is Protective against Sepsis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992351
Modern Language Association (MLA)
Zhu, Shu…[et al.]. It Is Not Just Folklore: The Aqueous Extract of Mung Bean Coat Is Protective against Sepsis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-992351
American Medical Association (AMA)
Zhu, Shu& Li, Wei& Li, Jianhua& Jundoria, Arvin& Sama, Andrew E.& Wang, Haichao. It Is Not Just Folklore: The Aqueous Extract of Mung Bean Coat Is Protective against Sepsis. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-992351
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992351