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Bone Micro-CT Assessments in an Orchidectomised Rat Model Supplemented with Eurycoma longifolia
Joint Authors
Shuid, Ahmad Nazrun
Ramli, Rosmaliza
Khamis, Mohd Fadhli
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Recent studies suggested that Eurycoma longifolia, a herbal plant, may have the potential to treat osteoporosis in elderly male.
This study aimed to determine the effects of Eurycoma longifolia supplementation on the trabecular bone microarchitecture of orchidectomised rats (androgen-deficient osteoporosis model).
Forty-eight-aged (10–12 months old) Sprague Dawley rats were divided into six groups of sham-operated (SHAM), orchidectomised control (ORX), orchidectomised + 7 mg/rat testosterone enanthate (TEN) and orchidectomised + Eurycoma longifolia 30 mg/kg (EL30), orchidectomised + Eurycoma longifolia 60 mg/kg (EL60), orchidectomised + Eurycoma longifolia 90 mg/kg (EL90).
Rats were euthanized following six weeks of treatment.
The left femora were used to measure the trabecular bone microarchitecture using micro-CT.
Orchidectomy significantly decreased connectivity density, trabecular bone volume, and trabecular number compared to the SHAM group.
Testosterone replacement reversed all the orchidectomy-induced changes in the micro-CT parameters.
EL at 30 and 60 mg/kg rat worsened the trabecular bone connectivity density and trabecular separation parameters of orchidectomised rats.
EL at 90 mg/kg rat preserved the bone volume.
High dose of EL (90 mg/kg) may have potential in preserving the bone microarchitecture of orchidectomised rats, but lower doses may further worsen the osteoporotic changes.
American Psychological Association (APA)
Ramli, Rosmaliza& Khamis, Mohd Fadhli& Shuid, Ahmad Nazrun. 2012. Bone Micro-CT Assessments in an Orchidectomised Rat Model Supplemented with Eurycoma longifolia. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992354
Modern Language Association (MLA)
Ramli, Rosmaliza…[et al.]. Bone Micro-CT Assessments in an Orchidectomised Rat Model Supplemented with Eurycoma longifolia. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-992354
American Medical Association (AMA)
Ramli, Rosmaliza& Khamis, Mohd Fadhli& Shuid, Ahmad Nazrun. Bone Micro-CT Assessments in an Orchidectomised Rat Model Supplemented with Eurycoma longifolia. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992354