Antiviral Ability of Kalanchoe gracilis Leaf Extract against Enterovirus 71 and Coxsackievirus A16
Joint Authors
Chang, Yuan-Shiun
Zhang, Yongjun
Lai, Zhen-Rung
Lin, Cheng-Wen
Wang, Ching-Ying
Huang, Shun-Chueh
Kung, Szu-Hao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Pandemic infection or reemergence of Enterovirus 71 (EV71) and coxsackievirus A16 (CVA16) occurs in tropical and subtropical regions, being associated with hand-foot-and-mouth disease, herpangina, aseptic meningitis, brain stem encephalitis, pulmonary edema, and paralysis.
However, effective therapeutic drugs against EV71 and CVA16 are rare.
Kalanchoe gracilis (L.) DC is used for the treatment of injuries, pain, and inflammation.
This study investigated antiviral effects of K.
gracilis leaf extract on EV71 and CVA16 replications.
HPLC analysis with a C-18 reverse phase column showed fingerprint profiles of K.
gracilis leaf extract had 15 chromatographic peaks.
UV/vis absorption spectra revealed peaks 5, 12, and 15 as ferulic acid, quercetin, and kaempferol, respectively.
K.
gracilis leaf extract showed little cytotoxicity, but exhibited concentration-dependent antiviral activities including cytopathic effect, plaque, and virus yield reductions.
K.
gracilis leaf extract was shown to be more potent in antiviral activity than ferulic acid, quercetin, and kaempferol, significantly inhibiting in vitro replication of EV71 (IC50=35.88 μg/mL) and CVA16 (IC50=42.91 μg/mL).
Moreover, K.
gracilis leaf extract is a safe antienteroviral agent with the inactivation of viral 2A protease and reduction of IL-6 and RANTES expressions.
American Psychological Association (APA)
Wang, Ching-Ying& Huang, Shun-Chueh& Zhang, Yongjun& Lai, Zhen-Rung& Kung, Szu-Hao& Chang, Yuan-Shiun…[et al.]. 2012. Antiviral Ability of Kalanchoe gracilis Leaf Extract against Enterovirus 71 and Coxsackievirus A16. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-992357
Modern Language Association (MLA)
Wang, Ching-Ying…[et al.]. Antiviral Ability of Kalanchoe gracilis Leaf Extract against Enterovirus 71 and Coxsackievirus A16. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-992357
American Medical Association (AMA)
Wang, Ching-Ying& Huang, Shun-Chueh& Zhang, Yongjun& Lai, Zhen-Rung& Kung, Szu-Hao& Chang, Yuan-Shiun…[et al.]. Antiviral Ability of Kalanchoe gracilis Leaf Extract against Enterovirus 71 and Coxsackievirus A16. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-992357
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992357