Kidney-Tonifying Recipe Can Repair Alterations in Adrenal Medullary Chromaffin Cells in Asthmatic Rats
Joint Authors
Hu, Cheng-Ping
Zou, Jun-Tao
Zou, Ye-Qiang
Li, Xiao-Zhao
Feng, Jun-Tao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Traditional Chinese medicine suggests that renal deficiency is a causative factor of asthma, and tonifying kidney drugs are believed to be an appropriate and beneficial treatment.
The adrenal medullary chromaffin cells (AMCC) transition to the neuronal phenotype is known to occur in asthma, as evidenced by degranulation of chromaffin granules, decline of epinephrine (EPI) and phenylethanolamine-n-methyl transferase (PNMT), and obvious alterations in cellular architecture.
In this study, rats were sensitized and challenged with ovalbumin, then treated with Kidney-Tonifying Recipe (KTR) to evaluate the therapeutic effect.
Tissues were evaluated for changes in pathology and EPI, PNMT, and peripherin expression.
Degranulation of chromaffin granules and appearance of neurite-like process were found in AMCC from asthmatic rats, and these changes were corrected by KTR treatment.
EPI and PNMT expressions were decreased in asthmatic rats and increased by KTR treatment.
Peripherin expression was increased in asthmatic rats and decreased in the KTR-treated group.
Morphological changes and decreases in EPI were observed when cultured AMCC were exposed to sera from asthmatic rats in vitro, and these changes were attenuated with the addition of sera from KRT-treated rats.
These results suggest that the Kidney-Tonifying Recipe is capable of repairing asthma-associated alterations in endocrine function and the ultrastructure of AMCC.
American Psychological Association (APA)
Hu, Cheng-Ping& Zou, Jun-Tao& Zou, Ye-Qiang& Li, Xiao-Zhao& Feng, Jun-Tao. 2012. Kidney-Tonifying Recipe Can Repair Alterations in Adrenal Medullary Chromaffin Cells in Asthmatic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992399
Modern Language Association (MLA)
Hu, Cheng-Ping…[et al.]. Kidney-Tonifying Recipe Can Repair Alterations in Adrenal Medullary Chromaffin Cells in Asthmatic Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-992399
American Medical Association (AMA)
Hu, Cheng-Ping& Zou, Jun-Tao& Zou, Ye-Qiang& Li, Xiao-Zhao& Feng, Jun-Tao. Kidney-Tonifying Recipe Can Repair Alterations in Adrenal Medullary Chromaffin Cells in Asthmatic Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992399