Pharmacological Basis for the Medicinal Use of Lepidium sativum in Airways Disorders
Joint Authors
Alkharfy, Khalid M.
Rehman, Najeeb-ur
Khan, Arif-ullah
Gilani, Anwarul Hassan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Lepidium sativum is widely used in folk medicine for treatment of hyperactive airways disorders, such as asthma, bronchitis and cough.
The crude extract of Lepidium sativum (Ls.Cr) inhibited carbachol (CCh, 1 μM-) and K+ (80 mM-) induced contractions in a pattern similar to that of dicyclomine.
Ls.Cr at 0.03 mg/mL produced a rightward parallel shift of CCh curves, followed by nonparallel shift at higher concentration (0.1 mg/mL), suppressing maximum response, similar to that caused by dicyclomine.
Pretreatment of tissues with Ls.Cr (0.1–0.3 mg/mL) shifted Ca++ concentration-response curves (CRCs) to right, as produced by verapamil.
Ls.Cr at low concentrations (0.03–0.1 mg/mL) caused leftward shift of isoprenaline-induced inhibitory CRCs, like that caused by rolipram, a phosphodiesterase (PDE) inhibitor.
These results indicate that bronchodilatory effect of Lepidium sativum is mediated through a combination of anticholinergic, Ca++ antagonist and PDE inhibitory pathways, which provides sound mechanistic background for its medicinal use in the overactive airways disorders.
American Psychological Association (APA)
Rehman, Najeeb-ur& Khan, Arif-ullah& Alkharfy, Khalid M.& Gilani, Anwarul Hassan. 2011. Pharmacological Basis for the Medicinal Use of Lepidium sativum in Airways Disorders. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992441
Modern Language Association (MLA)
Rehman, Najeeb-ur…[et al.]. Pharmacological Basis for the Medicinal Use of Lepidium sativum in Airways Disorders. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-992441
American Medical Association (AMA)
Rehman, Najeeb-ur& Khan, Arif-ullah& Alkharfy, Khalid M.& Gilani, Anwarul Hassan. Pharmacological Basis for the Medicinal Use of Lepidium sativum in Airways Disorders. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992441
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992441