Involvement of Prohibitin Upregulation in Abrin-Triggered Apoptosis
Joint Authors
Liu, Yu-Huei
Peck, Konan
Lin, Jung-Yaw
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Abrin (ABR), a protein purified from the seeds of Abrus precatorius, induces apoptosis in various types of cancer cells.
However, the detailed mechanism remains largely uncharacterized.
By using a cDNA microarray platform, we determined that prohibitin (PHB), a tumor suppressor protein, is significantly upregulated in ABR-triggered apoptosis.
ABR-induced upregulation of PHB is mediated by the stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK) pathway, as demonstrated by chemical inhibitors.
In addition, ABR significantly induced the expression of Bax as well as the activation of caspase-3 and poly(ADP-ribose) polymerase (PARP) in Jurkat T cells, whereas the reduction of PHB by specific RNA interference delayed ABR-triggered apoptosis through the proapoptotic genes examined.
Moreover, our results also indicated that nuclear translocation of the PHB-p53 complex may play a role in the transcription of Bax.
Collectively, our data show that PHB plays a role in ABR-induced apoptosis, which may be helpful for the development of diagnostic or therapeutic agents.
American Psychological Association (APA)
Liu, Yu-Huei& Peck, Konan& Lin, Jung-Yaw. 2011. Involvement of Prohibitin Upregulation in Abrin-Triggered Apoptosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-992449
Modern Language Association (MLA)
Liu, Yu-Huei…[et al.]. Involvement of Prohibitin Upregulation in Abrin-Triggered Apoptosis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-992449
American Medical Association (AMA)
Liu, Yu-Huei& Peck, Konan& Lin, Jung-Yaw. Involvement of Prohibitin Upregulation in Abrin-Triggered Apoptosis. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-992449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992449