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Salidroside Decreases Atherosclerotic Plaque Formation in Low-Density Lipoprotein Receptor-Deficient Mice
Joint Authors
Zhang, Bu-Chun
Li, Wei-Ming
Guo, Rong
Xu, Ya-Wei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Salidroside is isolated from Rhodiola rosea and is one of the main active components in Rhodiola species.
The present study was designed to evaluate the effects of Salidroside on atherosclerotic plaque formation in high-fat diet-(HFD-) fed female LDL receptor knockout (LDLr-/-) mice.
LDLr-/- mice fed an atherogenic HFD for 12 weeks were divided into two groups.
One group was administered Salidroside (50 mg/kg/oral gavage) daily for 8 weeks, while the control group was administered saline.
Salidroside treatment reduced serum lipids levels and the plaque area through the arch to the abdominal aorta.
Furthermore, Salidroside improved macrophage content and enhanced collagen and smooth muscle cells contents in the aortic sinus.
These changes were associated with reduced MCP-1, VCAM-1, and VCAM-1 protein expression in atherosclerotic aortas.
All these results suggest that Salidroside decreases atherosclerotic plaques formation via effects on lipid lowering and anti-inflammation in HFD-fed LDLr−/− mice.
American Psychological Association (APA)
Zhang, Bu-Chun& Li, Wei-Ming& Guo, Rong& Xu, Ya-Wei. 2012. Salidroside Decreases Atherosclerotic Plaque Formation in Low-Density Lipoprotein Receptor-Deficient Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-992453
Modern Language Association (MLA)
Zhang, Bu-Chun…[et al.]. Salidroside Decreases Atherosclerotic Plaque Formation in Low-Density Lipoprotein Receptor-Deficient Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-992453
American Medical Association (AMA)
Zhang, Bu-Chun& Li, Wei-Ming& Guo, Rong& Xu, Ya-Wei. Salidroside Decreases Atherosclerotic Plaque Formation in Low-Density Lipoprotein Receptor-Deficient Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-992453
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992453