Acute and 28-Day Subchronic Oral Toxicity of an Ethanol Extract of Zingiber zerumbet (L.) Smith in Rodents
Joint Authors
Liou, Shorong-Shii
Chang, Chia Ju
Tzeng, Thing-Fong
Liou, Shorong-Shii
Liu, I-Min
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The objective of this study was to evaluate the acute and subacute toxicity (28 days) of the ethanol extract of Z.
zerumbet rhizomes (EEZZ) via the oral route in Wistar rats of both sexes.
In the acute toxicity study, Wistar rats were administered a single dose of 15 g kg−1 of body weight by gavage, and were monitored for 14 days.
EEZZ did not produce any toxic signs or deaths; the 50% lethal dose must be higher than 15 g kg−1.
In the subchronic toxicity study, EEZZ was administered by gavage at doses of 1000, 2000 and 3000 mg/kg daily for 4 weeks to Wistar rats.
The subacute treatment with EEZZ did not alter either the body weight gain or the food and water consumption.
The hematological and biochemical analysis did not show significant differences in any of the parameters examined in female or male groups.
Necropsy and histopathological examination, did not reveal any remarkable and treatment related changes.
A no-observed adverse-effect level for EEZZ is 3000 mg kg−1 for rats under the conditions of this study.
Hence, consumption of EEZZ for various medicinal purposes is safe.
American Psychological Association (APA)
Chang, Chia Ju& Tzeng, Thing-Fong& Liou, Shorong-Shii& Liou, Shorong-Shii& Liu, I-Min. 2012. Acute and 28-Day Subchronic Oral Toxicity of an Ethanol Extract of Zingiber zerumbet (L.) Smith in Rodents. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-992457
Modern Language Association (MLA)
Chang, Chia Ju…[et al.]. Acute and 28-Day Subchronic Oral Toxicity of an Ethanol Extract of Zingiber zerumbet (L.) Smith in Rodents. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-992457
American Medical Association (AMA)
Chang, Chia Ju& Tzeng, Thing-Fong& Liou, Shorong-Shii& Liou, Shorong-Shii& Liu, I-Min. Acute and 28-Day Subchronic Oral Toxicity of an Ethanol Extract of Zingiber zerumbet (L.) Smith in Rodents. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-992457
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992457