Bambusae caulis in Liquamen Suppresses the Expression of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine in Human Keratinocytes due to Antioxidant Effect
Joint Authors
Lee, Kyu-Jae
Qi, Xu-Feng
Kim, Dong-Heui
Yoon, Yang-Suk
Song, Soon-Bong
Teng, Yung-Chien
Cai, Dong-Qing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Bambusae caulis in Liquamen (BCL), traditional herbal medicine used in East Asia, is known to have antioxidative and immune-regulating properties.
We hypothesized that the potential antioxidant effects of BCL might suppress the production of thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) in human keratinocytes (HaCaT cell).
The immune-regulating effect of BCL was demonstrated by antioxidant capacity using DPPH analysis and DCFH-DA analysis.
We found that BCL had strong ROS scavenge effect in HaCaT cell.
BCL also showed suppression of IFN-γ-induced expression of TARC and MDC, activation of NF-κB, and, moreover, significant block of IFN-γ-induced degradation and phosphorylation of IκB.
However, it had no effects on phosphorylation of p38 MAPK.
Collectively, these results suggest that BCL may have a therapeutic potential on skin disease such as atopic dermatitis by inhibiting Th2 chemokines which is due, at least in part, to its antioxidant capacities.
American Psychological Association (APA)
Qi, Xu-Feng& Kim, Dong-Heui& Yoon, Yang-Suk& Song, Soon-Bong& Teng, Yung-Chien& Cai, Dong-Qing…[et al.]. 2011. Bambusae caulis in Liquamen Suppresses the Expression of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine in Human Keratinocytes due to Antioxidant Effect. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992463
Modern Language Association (MLA)
Qi, Xu-Feng…[et al.]. Bambusae caulis in Liquamen Suppresses the Expression of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine in Human Keratinocytes due to Antioxidant Effect. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-992463
American Medical Association (AMA)
Qi, Xu-Feng& Kim, Dong-Heui& Yoon, Yang-Suk& Song, Soon-Bong& Teng, Yung-Chien& Cai, Dong-Qing…[et al.]. Bambusae caulis in Liquamen Suppresses the Expression of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine in Human Keratinocytes due to Antioxidant Effect. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992463