Analysis of Flavonoids from Eugenia uniflora Leaves and Its Protective Effect against Murine Sepsis
Joint Authors
Rattmann, Yanna D.
de Souza, Lauro Mera
Malquevicz-Paiva, Simone M.
Dartora, Nessana
Sassaki, Guilherme Lanzi
Gorin, Philip A. J.
Iacomini, Marcello
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Eugenia uniflora, referred to as Pitanga cherry shrub, is largely distributed in tropical and subtropical America.
This plant is cultivated in many countries and it is suitable for the production of juice, frozen pulp, and tea.
Besides, it can be used as treatment for inflammatory diseases.
We reported that a flavonoid-rich fraction (HE-Bu) obtained from leaves decreased the lethality induced by cecal ligation and puncture (CLP), a clinically relevant model of sepsis.
The oral administration of HE-Bu reduced the late mortality rate by 30%, prevented neutrophil accumulation in lungs, decreased TNF-α and IL-1β serum levels, and markedly decreased iNOS and COX-2 protein expression by ileum cells.
Chemical investigation showed myricetin and quercetin rhamnosides as the major components of this fraction.
The results showed that HE-Bu protected mice from sepsis and indicated that this edible plant produces compounds that could be considered as potential adjuvants for sepsis treatment.
American Psychological Association (APA)
Rattmann, Yanna D.& de Souza, Lauro Mera& Malquevicz-Paiva, Simone M.& Dartora, Nessana& Sassaki, Guilherme Lanzi& Gorin, Philip A. J.…[et al.]. 2012. Analysis of Flavonoids from Eugenia uniflora Leaves and Its Protective Effect against Murine Sepsis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992470
Modern Language Association (MLA)
Rattmann, Yanna D.…[et al.]. Analysis of Flavonoids from Eugenia uniflora Leaves and Its Protective Effect against Murine Sepsis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-992470
American Medical Association (AMA)
Rattmann, Yanna D.& de Souza, Lauro Mera& Malquevicz-Paiva, Simone M.& Dartora, Nessana& Sassaki, Guilherme Lanzi& Gorin, Philip A. J.…[et al.]. Analysis of Flavonoids from Eugenia uniflora Leaves and Its Protective Effect against Murine Sepsis. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-992470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992470