Metabolomics-Based Study of Clinical and Animal Plasma Samples in Coronary Heart Disease with Blood Stasis Syndrome
Joint Authors
Zhao, Huihui
Chen, Jianxin
Shi, Qi
Ma, Xueling
Yang, Yi
Luo, Liangtao
Guo, Shuzhen
Wang, Yong
Han, Jing
Wang, Wei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aim of this study is to explore a bridge connecting the mechanism basis and macro syndromes of coronary heart disease with experimental animal models.
GC-MS technique was used to detect the metabolites of plasma samples in mini swine models with myocardial infarction (MI) and patients with unstable angina (UA).
30 metabolites were detected in the plasma samples of more than 50 percent of model group and control group in swine, while 37 metabolites were found in the plasma samples of UA patients and healthy control group.
21 metabolites in the plasma samples of swine model and 20 metabolites in patients with UA were found of significant value.
Among which, 8 shared metabolites were found of low level expression in both swine model and UA patients.
Independent Student’s t-test, principal component analysis (PCA), and hierarchicalcluster analysis (HCA) were orderly applied to comprehend inner rules of variables in the data.
The 8 shared metabolites could take place of the 21 or 20 metabolites in classification of swine model with MI and UA patients, which could be considered as a bridge connecting the mechanism basis and macrosyndromes of swine model with MI and UA patients.
American Psychological Association (APA)
Zhao, Huihui& Chen, Jianxin& Shi, Qi& Ma, Xueling& Yang, Yi& Luo, Liangtao…[et al.]. 2012. Metabolomics-Based Study of Clinical and Animal Plasma Samples in Coronary Heart Disease with Blood Stasis Syndrome. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-992488
Modern Language Association (MLA)
Zhao, Huihui…[et al.]. Metabolomics-Based Study of Clinical and Animal Plasma Samples in Coronary Heart Disease with Blood Stasis Syndrome. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-992488
American Medical Association (AMA)
Zhao, Huihui& Chen, Jianxin& Shi, Qi& Ma, Xueling& Yang, Yi& Luo, Liangtao…[et al.]. Metabolomics-Based Study of Clinical and Animal Plasma Samples in Coronary Heart Disease with Blood Stasis Syndrome. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-992488
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992488